Andrew Coxon

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1. Total body areal bone mineral density was measured by dual-energy X-ray absorptiometry in eight women before and 10 weeks after a very-low-calorie diet [405 kcal (1701 kJ)/day]. 2. The mean weight loss of 15.6 kg was accompanied by a statistically significant reduction in total body bone mineral density from 1.205 +/- 0.056 to 1.175 +/- 0.058 g/cm2 (mean(More)
Glycogen is stored in the liver, muscles, and fat cells in hydrated form (three to four parts water) associated with potassium (0.45 mmol K/g glycogen). Total body potassium (TBK) changes early in very-low-calorie diets (VLCDs) primarily reflect glycogen storage. Potassium released from glycogen can distort estimates of body composition during dieting. TBK(More)
Recently Aitken introduced an outstanding advance in the approach to decision making regarding drugs sampling. Unfortunately this approach has not, as yet, been widely implemented despite being based on a solid mathematical foundation. In this paper we advocate a Bayesian approach along the lines of that outlined by Aitken but designed to be both easily(More)
Fat-free mass was measured by hydrodensitometry, electrical impedance and total body potassium before and after water and electrolyte loss induced by (a) the administration of the diuretic frusemide, and (b) sweat loss. All methods of measuring fat-free mass were shown by pilot experiments to have procedural reliability. The diuretic caused a reduction in(More)
The challenge to maintain lost weight is particularly relevant for advocates of VLCD, since these induce a high rate of weight loss. It has been argued that excessive lean body mass is lost with very restricted energy intake regimens which compromises metabolic rate and sabotages weight maintenance. Thirty-nine subjects who had lost an average of 12.3 +/- 2(More)
Comment Fraser et all in their original description of legionnaires' disease referred to three patients out of 182 with a WCC less than 2.0 x 109/1, two of whom died. Two other patients had WCCs of less than 6 0 x 109/1. During his acute illness our patient had pancytopenia with bone marrow depression. We can only speculate on the part played by(More)
Body composition was assessed in naturally lean female subjects who never had need to diet. At BMI 21-22 their body weight distribution of 75 per cent FFM and 25 per cent fat was compared with subjects who had dieted below BMI 25 by various conventional self-selected diets; subjects who had dieted to BMI 21-22 by VLCD and subjects who were dieting with VLCD(More)
The effect of very low calorie diet (VLCD) on fat-free mass (FFM) and physiological response to exercise is a topic of current interest. Ten moderately obese women (aged 23-57 years) received VLCD (1695 for 6 weeks. FFM, estimated by four conventional techniques, and heart rate (fc), blood lactate (la(b)), mean arterial pressure (MAP), respiratory(More)