Andrew Charles Mallory Austin

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Noncoding expansions of a hexanucleotide repeat (GGGGCC) in the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis and frontotemporal dementia. Here we report transgenic mice carrying a bacterial artificial chromosome (BAC) containing the full human C9orf72 gene with either a normal allele (15 repeats) or disease-associated(More)
ALS therapy development has been hindered by the lack of rodent animal models. The discovery of TDP-43, a transcription factor that accumulates in the cytoplasm of motor neurons (MNs) in most cases of ALS, prompted attempts to develop TDP-43-based models of the disease. The current study sought to examine, in extensive detail, the emerging disease phenotype(More)
Hardware imperfections can significantly reduce the performance of full-duplex wireless systems by introducing non-idealities and random effects that make it challenging to fully suppress self-interference. Previous research has mostly focused on analyzing the impact of hardware imperfections on full-duplex systems, based on simulations and theoretical(More)
The paper describes the implementation and performance analysis of the first fully-operational beam-space MIMO antenna for the spatial multiplexing of two QPSK streams. The antenna is composed of a planar three-port radiator with two varactor diodes terminating the passive ports. Pattern reconfiguration is used to encode the MIMO information onto orthogonal(More)
Clinical presentation of spinal muscular atrophy (SMA) ranges from a neonatal-onset, very severe disease to an adult-onset, milder form. SMA is caused by the mutation of the Survival Motor Neuron 1 (SMN1) gene, and prognosis inversely correlates with the number of copies of the SMN2 gene, a human-specific homolog of SMN1. Despite progress in identifying(More)
—In a cognitive radio system the failure of secondary user (SU) transceivers to promptly vacate the channel can introduce significant access-latency for primary or high-priority users (PU). In conventional cognitive radio systems, the backoff latency is exacerbated by frame structures that only allow sensing at periodic intervals. Concurrent transmission(More)
A demonstration of a cognitive radio network that supports concurrent spectrum sensing and transmission is presented. To detect primary users while transmitting, the secondary user node must suppress the self-interference signals. The system is implemented on a National Instruments Universal Software Radio Peripheral (USRP) platform. The demonstration will(More)
Acknowledgements First I would like to acknowledge my thesis director Prof. A. Burg for the allocation of my research position. I want to outline here his unrivaled gift to provide comments that transform any text into a piece which reads like a scientific publication. Further, I would like to thank deserves my additional gratitude not only for kindly(More)
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