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DNA lesions that arrest replication can lead to rearrangements, mutations, or lethality when not processed accurately. After UV-induced DNA damage in Escherichia coli, RecA and several recF pathway proteins are thought to process arrested replication forks and ensure that replication resumes accurately. Here, we show that the RecJ nuclease and RecQ(More)
Replication forks face a variety of structurally diverse impediments that can prevent them from completing their task. The mechanism by which cells overcome these hurdles is likely to vary depending on the nature of the obstacle and the strand in which the impediment is encountered. Both UV-induced DNA damage and thermosensitive replication proteins have(More)
Matlab is a popular language for scientific computation. Effectively compiling Matlab presents many challenges due to the dynamic nature of the language. We present McLab, an extensible compiler toolkit for the Matlab and related languages. McLab aims to provide high performance execution of Matlab on modern architectures while bringing modern programming(More)
<b>MATLAB</b> is a popular language for scientific computation, used by millions of students, scientists and engineers world-wide. The <b>McLAB</b> project aims to provide an open source compiler and virtual machine infrastructure to enable programming language, compiler and software engineering researchers to work in this important area.
Dynamic nuclear polarization is combined with temperature-jump methods to develop a new 2D 13C-13C NMR experiment that yields a factor of 100-170 increase in sensitivity. The polaization step is performed at 100 K, and the sample is subsequently melted with a 10.6 microm laser pulse to yield a sample with highly polarized 13C spins. 13C detected 2D 13C-13C(More)
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