Diffuse intrinsic pontine glioma (DIPG) is a fatal brain cancer that arises in the brainstem of children, with no effective treatment and near 100% fatality. The failure of most therapies can be attributed to the delicate location of these tumors and to the selection of therapies on the basis of assumptions that DIPGs are molecularly similar to adult… (More)
BACKGROUND Computer image analysis techniques have decreased effects of observer biases, and increased the sensitivity and the throughput of immunohistochemistry (IHC) as a tissue-based procedure for the evaluation of diseases. METHODS We adapted a Cyan/Magenta/Yellow/Key (CMYK) model for automated computer image analysis to quantify IHC stains in… (More)
Pediatric ependymomas are highly recurrent tumors resistant to conventional chemotherapy. Telomerase, a ribonucleoprotein critical in permitting limitless replication, has been found to be critically important for the maintenance of tumor-initiating cells (TICs). These TICs are chemoresistant, repopulate the tumor from which they are identified, and are… (More)
Ependymomas are the third most common pediatric brain tumor with an overall survival of approximately 50%. Recently, we showed that telomerase [human telomerase reverse transcriptase (hTERT)] expression is a predictor of poor outcome in pediatric ependymoma. Thus, we hypothesized that ependymomas with functional telomerase may behave more aggressively and… (More)
Pediatric high-grade astrocytomas (HGAs) account for 15-20% of all pediatric central nervous system tumors. These neoplasms predominantly involve the supratentorial hemispheres or the pons--diffuse intrinsic pontine gliomas (DIPG). Assumptions that pediatric HGAs are biologically similar to adult HGAs have recently been challenged, and the development of… (More)
Off-the-Record messaging is a protocol for enabling secure, authenticated, deniable messaging with perfect forward secrecy , specifically over instant messaging networks. In this paper we describe the results of a finite-state security analysis of the OTR protocol. In addition to finding several security issues in the process of modeling the protocol, our… (More)
Here we report on the photocurrent response of two-dimensional (2D) heterostructures of sputtered MoS 2 on boron nitride (BN) deposited on (001)-oriented Si substrates. The steady state photocurrent (I ph) measurements used a continuous laser of k 5 658 nm (E 5 1.88 eV) over a broad range of laser intensities, P (;1 lW , P , 10 lW), and indicate that I ph… (More)
We expose a rule for multiplying a general Schubert polynomial with a power sum polynomial in k variables. A signed sum over cyclic permutations replaces the signed sum over rim hooks in the classical Murgnahan– Nakayama rule. In the intersection theory of flag manifolds this computes all intersections of Schubert cycles with tautological classes coming… (More)
We prove a formula, originally due to Feit and Fine, for the class of the commuting variety in the Grothendieck group of varieties. Our method, which uses a power structure on the Grothendieck group of stacks, allows us to prove several refinements and generalizations of the Feit-Fine formula. Our main application is to motivic Donaldson-Thomas theory.
Background: Computer image analysis techniques have decreased effects of observer biases, and increased the sensitivity and the throughput of immunohistochemistry (IHC) as a tissue-based procedure for the evaluation of diseases.