Andrew Butcher

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Data miners can infer rules showing how to improve either (a) the effort estimates of a project or (b) the defect predictions of a software module. Such studies often exhibit conclusion instability regarding what is the most effective action for different projects or modules.
Existing research is unclear on how to generate lessons learned for defect prediction and effort estimation. Should we seek lessons that are global to multiple projects or just local to particular projects? This paper aims to comparatively evaluate local versus global lessons learned for effort estimation and defect prediction. We applied automated(More)
The fundamental chemistry of trace elements dictates the molecular speciation and reactivity both within cells and the environment at large. Using protein structure and comparative genomics, we elucidate several major influences this chemistry has had upon biology. All of life exhibits the same proteome size-dependent scaling for the number of metal-binding(More)
Eggs of a small intestinal trematode were found in the faeces of two 21-month-old children from the same rural district of South Australia who presented 18 months apart with mild abdominal pain and diarrhoea. Treatment with praziquantel resulted in egg clearance and resolution of gastrointestinal symptoms. A brachylaimid intestinal trematode involving the(More)
The life-cycle of Brachylaima cribbi n. sp. was established in the laboratory. Asymmetrical brachylaimid eggs, measuring 26-32 μm (29.1μm) long and 16 -17.5 μm (16.6μm) wide, were recovered from human faeces and fed to the helicid land snail Theba pisana as the first intermediate host. Sporocysts and cercariae were recovered from the T. pisana eight weeks(More)
A 78-year-old woman presented with an 18-month history of intermittent diarrhoea. Examination of her stools revealed brachylaimid eggs, which were present in three separate specimens over a week. After treatment with praziquantel a degenerate adult Brachylaima species was recovered from her faeces. She lived in a rural area of South Australia and ate(More)
Susceptibility to infection with Brachylaima cribbi was studied in eight strains of inbred mice (AKR, C3H/HeJ, CBA/CaH, BALB/c, DBA/2J, SJL/J, A/J, C57BL/6J) and Swiss albino outbred mice by quantifying faecal egg excretion over the period of the infection. Preliminary experiments indicated that a combination of filtration/sedimentation/diethyl ether(More)
BACKGROUND It has been postulated that bacterial biofilms are involved in the pathogenesis of chronic rhinosinusitis (CRS). Biofilms present on sinus mucosa are difficult to eradicate with conventional antibiotic therapy and are thought to provide a nidus for recurrent infection. Topical delivery of antibiotics via nasal irrigation may present a way of(More)
The course of infection in C57BL/6J mice re-infected with Brachylaima cribbi was assessed by comparing faecal egg excretion of re-infected mice with age- and sex-matched mice receiving a primary infection only. For both male and female mice there was a significant reduction in the mean number of eggs per gram of faeces at the peak of infection 4 weeks after(More)
It is probable that the majority of the 455 000 strong Aboriginal population of Australia speak some form of Australian Aboriginal English (AAE) at least some of the time and that it is the first (and only) language of many Aboriginal children. This means their language is somewhere on a continuum ranging from something very close to Standard Australian(More)