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Decision Modelling for Health Economic Evaluation
In financially constrained health systems across the world, increasing emphasis is being placed on the ability to demonstrate that health care interventions are not only effective, but alsoExpand
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Searching for a threshold, not setting one: the role of the National Institute for Health and Clinical Excellence
There has been much speculation about whether the National Institute for Health and Clinical Excellence (NICE) has, or ought to have, a 'threshold' figure for the cost of an additionalExpand
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Probabilistic analysis of cost-effectiveness models: statistical representation of parameter uncertainty.
  • Andrew Briggs
  • Computer Science, Medicine
  • Value in health : the journal of the…
  • 2005
We present a probabilistic model that typifies the approach to presentinguncertainty in cost-effectiveness models by characterizing the input parameters of their modelas probability distributions, the authors are able topropagate that uncertainty through the model using Monte Carlo simulation, thus generating a jointdistribution in the incremental costs and effectsthat represents the consequences of the input para-meter uncertainty. Expand
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Discounting and cost-effectiveness in NICE - stepping back to sort out a confusion.
Brouwer and colleagues [1] argue that the reasons for specifying an equal discount rate for health outcomes and costs in the recent guidance on methods of technology appraisal issued by the NationalExpand
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Value based pricing for NHS drugs: an opportunity not to be missed?
The policy debate about price, value, and innovation in pharmaceuticals is at a critical stage for the NHS. Claxton and colleagues describe the key principles of value based pricing and consider someExpand
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Improving the efficiency and relevance of health technology assessent: the role of iterative decision analytic modelling
Decision making in health care involves two sets of related decisions: those concerning appropriate service provision on the basis of existing information; and those concerned with whether to fundExpand
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The Ends Justify the Mean: Outcome Measures for Estimating the Value of New Cancer Therapies
Abstract Objective Overall survival is a commonly reported end point in clinical trial publications and a key determinant of therapies’ cost-effectiveness. Patients’ survival times have skewedExpand
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The Design and Analysis of Stochastic Cost-Effectiveness Studies for the Evaluation of Health Care Interventions
Many clinical trials are in progress that involve the collection of patient-level data on both the health outcome and resource use consequences of the health care interventions under evaluation. TheExpand
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Computer modeling of diabetes and its complications: a report on the Fifth Mount Hood challenge meeting.
OBJECTIVES The Mount Hood Challenge meetings provide a forum for computer modelers of diabetes to discuss and compare models, to assess predictions against data from clinical trials and otherExpand
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