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- Andrea H Bild, Guang Qing Yao, +12 authors J. R. Nevins
- Nature
- 2006
Tumour profiling advancesMolecular tumour profiling is one way in which effective targeted cancer treatment regimes might be developed. Two groups report significant developments in this direction.… (More)
- Stig Egil Bojesen, Karen A. Pooley, +434 authors Alison M. Dunning
- Nature Genetics
- 2013
TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 SNPs at the TERT locus in… (More)
- Paul D P Pharoah, Ya-yu Tsai, +165 authors Thomas A. Sellers
- Nature Genetics
- 2013
Genome-wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome-wide significance. We pooled… (More)
- Honglin Song, Susan J Ramus, +82 authors Simon A. Gayther
- Nature Genetics
- 2009
Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explain less than half the excess familial risk. We performed a genome-wide association study (GWAS) to… (More)
- Celeste Leigh Pearce, Claire L. Templeman, +42 authors Andrew Berchuck
- The Lancet. Oncology
- 2012
BACKGROUND
Endometriosis is a risk factor for epithelial ovarian cancer; however, whether this risk extends to all invasive histological subtypes or borderline tumours is not clear. We undertook an… (More)
- Ellen L. Goode, Georgia Chenevix-Trench, +78 authors Penelope M Webb
- Nature Genetics
- 2010
Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify common low-penetrance ovarian cancer susceptibility genes, we conducted a genome-wide association… (More)
- Tsukasa Baba, Patricia A Convery, +10 authors Susan K. Murphy
- Oncogene
- 2009
The cancer stem cell hypothesis posits that malignant growth arises from a rare population of progenitor cells within a tumor that provide it with unlimited regenerative capacity. Such cells also… (More)
- Rebecca Therese Marquez, Keith A. Baggerly, +13 authors Karen H. Lu
- Clinical cancer research : an official journal of…
- 2005
PURPOSE
Epithelial ovarian cancers are thought to arise from flattened epithelial cells that cover the ovarian surface or that line inclusion cysts. During malignant transformation, different… (More)
- Karen H. Lu, Andrea P Patterson, +16 authors Robert C. Bast
- Clinical cancer research : an official journal of…
- 2004
PURPOSE
Advanced-stage epithelial ovarian cancer has a poor prognosis with long-term survival in less than 30% of patients. When the disease is detected in stage I, more than 90% of patients can be… (More)
- Holly Dressman, Andrew Berchuck, +14 authors Johnathan Mark Lancaster
- Journal of clinical oncology : official journal…
- 2007
PURPOSE
The purpose of this study was to develop an integrated genomic-based approach to personalized treatment of patients with advanced-stage ovarian cancer. We have used gene expression profiles… (More)