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Since the pioneering studies of Cooper et al. to influence epilepsy by cerebellar stimulation, numerous attempts have been made to reduce seizure frequency by stimulation of deep brain structures. Evidence from experimental animal studies suggests the existence of a nigral control of the epilepsy system. It is hypothesized that the dorsal midbrain(More)
PURPOSE Malformations of cortical development (MCDs) are a frequent cause of refractory epilepsy in humans. The in utero radiation model in rats shares many clinical and histopathologic characteristics with human MCDs. Previous studies reported the presence of clinical seizures in radiated rats, but also suggested a dose-dependent differential effect. (More)
We systematically examined 226 epilepsy patients in a tertiary-referral center and found 6 (5.04%) to have valproate-induced Parkinsonism. There was a significantly higher prevalence of patients with Parkinsonism in the group of patients treated with valproate compared to those who were on other antiepileptic drugs (6 [5.04%] of 119 vs. 0 [0%] of 107; chi2(More)
The electroclinical syndrome of benign focal epilepsy of childhood has been the subject of intense investigation over the past fifty years. Characteristic findings, over the years, of its signature electroencephalographic discharge, including morphology, topography, field of distribution, activation and reactivity will be presented and discussed.
PURPOSE Benign focal epileptiform discharges of childhood (BFEDCs) are common EEG findings between ages 4 and 14 years. This epoch of maturational development overlaps with the age at presentation of temporal lobe epilepsy (TLE) due to hippocampal sclerosis (HS) in children. METHODS From our series of 17 preadolescent children who eventually underwent(More)
Dear Editor, Cefasporins such as cefepime are beta-lactam antibiotics with a broad antimicrobial spectrum. They are commonly used as first-line agents in the treatment of many infections. 1 Reversible encephalopathy is a known neurotoxic complication of cefalosporins. 2 Previous case reports have documented triphasic waves on electroencephalography (EEG) in(More)
PURPOSE Knowledge, attitudes, and perceptions of epilepsy (KAPE) among the public play a major role in determining the extent to which people with epilepsy can be integrated into their society. KAPE SURVEYS IN ASIA Surveys conducted among Chinese in China, Taiwan, Malaysia, Singapore, and Hong Kong demonstrated similarities as well as differences in(More)
Quiz A 40-year-old Malay lady presented with a 6-month history of headache. She had a past history of a left nephrectomy 6 years ago. Neurological examination revealed generalised brisk limb reflexes and right ataxia. Additional clinical findings were a ballotable right kidney and bilateral retinal capillary hemangiomas. Brain magnetic resonance imaging(More)
Cranially conjoined twins are rare and pose unique challenges in the preoperative evaluation of cerebral language function. The authors report on their experience in the functional magnetic resonance (fMR) imaging evaluation of adult craniopagus (temporoparietooccipital fusion) to evaluate hemispheric language dominance and the eloquent language areas in(More)
Hotspot localization in the chip is the common and effective methodology in the Semiconductor Failure Analysis (FA), However, we often cannot proceed in the successful Physical Failure Analysis (PFA) via the first-generation hot spots. In the paper, we show one example with assistance of circuit analysis to perform the effectively physical fault isolation.(More)