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The forkhead domain containing transcription factor BF-1 has been shown to play a major role in the correct development of the cerebral hemispheres in the mouse. BF-1 orthologs have been isolated from zebrafish and the cephalocordate amphioxus. In both species, BF-1 is expressed in the anterior neural tube. In zebrafish zBF-1 expression is restricted to(More)
SPA is a synthesised, self-timed, ARM-compatible processor core. The use of synthesis was mandated by a need for rapid implementation. This has proved to be very effective , albeit with increased cost in terms of area and performance compared with earlier non-synthesised processors. SPA is employed in an experimental smartcard chip which is being designed(More)
Mutations in the tudor locus of Drosophila affect two distinct determinative processes in embryogenesis; segmentation of the abdomen and determination of the primordial germ cells. The distribution of tudor protein during embryogenesis, and the effect of various mutations on its distribution, suggest that tudor protein may carry out these functions(More)
—This paper describes a new target component set and synthesis scheme for the Balsa asynchronous hardware description language. This new scheme removes the reliance on precise handshake interleaving and enclosure by separating out control 'go' and 'done' signalling into separate channels rather than using different phases of the asynchronous handshake. This(More)
The tudor (tud) locus of Drosophila melanogaster is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. The tud locus was cloned, and its product was identified by Northern analysis of wild-type and tud mutant RNAs. The locus encodes a single mRNA of approximately 8.0 kb that is expressed throughout(More)
An in situ hybridization expression screen using a signal sequence trap system has been conducted in zebrafish to isolate cDNAs that encode secreted proteins. Random clones (secreted expressed sequence tags; sESTs) were sequenced from zebrafish embryonic (18-24 hr postfertilization) and adult kidney libraries. From the two RNA sources, 627 random sEST cDNAs(More)