Andrew B. Wright

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Chronic pain is very difficult to treat. Thus, novel analgesics are a critical area of research. Strong pre-clinical evidence supports the analgesic effects of α-conopeptides, Vc1.1 and RgIA, which block α9α10 nicotinic acetylcholine receptors (nAChRs). However, the analgesic mechanism is controversial. Some evidence supports the block of α9α10 nAChRs as an(More)
Recent development in lower limb prosthetics has seen an emergence of powered prosthesis that have the capability to operate in different locomotion modes. However, these devices cannot transition seamlessly between modes such as level walking, stair ascent and descent and up slope and down slope walking. They require some form of user input that defines(More)
Chronic pain is very difficult to treat. Thus, novel analgesics are a critical area of research. Strong preclinical evidence supports the analgesic effects of ␣-conopeptides, Vc1.1 and RgIA, which block ␣9␣10 nicotinic acetylcholine receptors (nAChRs). However, the analgesic mechanism is controversial. Some evidence supports the block of ␣9␣10 nAChRs as an(More)
Myoelectric control of lower limb prostheses requires discrimination of task-specific muscle patterns. In this paper we present a method based on the notion of muscle synergies to discriminate between various non-weight-bearing movements such as knee extension/flexion, femur rotation in/out, tibia rotation in/out and ankle dorsiflexion/plantarflexion. Data(More)
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