Andrew B. G. Bush

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A cold event at around 8200 calendar years BP and the release, at around that time, of a huge freshwater outburst from ice-dammed glacial Lake Agassiz have lent support to the idea that the flood triggered the cold event. Some suggest that the freshwater addition caused a weakening of the North Atlantic meridional overturning circulation (MOC) thereby(More)
Understanding the historical dynamics of forest communities is a critical element for accurate prediction of their response to future change. Here, we examine evergreen rainforest distribution in the Sunda Shelf region at the last glacial maximum (LGM), using a spatially explicit model incorporating geographic, paleoclimatic, and geologic evidence. Results(More)
Results from a coupled atmosphere-ocean general circulation model simulation of the Last Glacial Maximum reveal annual mean continental cooling between 48 and 78C over tropical landmasses, up to 268 of cooling over the Laurentide ice sheet, and a global mean temperature depression of 4.38C. The simulation incorporates glacial ice sheets, glacial land(More)
We report here that the expression of virtually all proposed c-Myc target genes is unchanged in cells containing a homozygous null deletion of c-myc. Two noteworthy exceptions are the gene cad, which has reduced log phase expression and serum induction in c-myc null cells, and the growth arrest gene gadd45, which is derepressed by c-myc knockout. Thus, cad(More)
A better understanding of the relationship between the El Niño Southern Oscillation (ENSO), the climatic anomalies it engenders, and malaria epidemics could help mitigate the world-wide increase in incidence of this mosquito-transmitted disease. The purpose of this paper is to assess the possibility of using ENSO forecasts for improving malaria control.(More)
The World Health Organization (WHO) reported that the 1997/98 El Niño might have been the cause of the dengue fever epidemics in many tropical countries. Because of the interaction between the atmosphere and the ocean, the warm El Niño and the cold La Niña phases of the El Niño Southern Oscillation (ENSO) engender significant temperature and precipitation(More)
The genes of the myc/max/mad family play an important role in controlling cell proliferation and differentiation. We have identified the first homologues of the mad and max genes in the nematode C. elegans, which we have named mdl-1 and mxl-1 respectively. Like the vertebrate MAD proteins, MDL-1 binds an E-box DNA sequence (CACGTG) when dimerized with(More)
The Quaternary glacial history of the world’s highest mountains, the Central Karakoram, is examined for the first time using geomorphic mapping of landforms and sediments, and Be terrestrial cosmogenic nuclide surface exposure dating of boulders on the moraines and glacially eroded surfaces. Four glacial stages are defined: the Bunthang glacial stage(More)
Genetic studies have uncovered many genes that are involved in the first steps of neuronal development in Drosophila. Less is known about the intermediate steps during which individual precursor cells follow either the neuronal pathway or the glial pathway. We report the identification of a novel bHLH gene, biparous, expressed in neuronal and glial(More)
[1] During the last glacial period, eustatic lowering of sea level exposed large areas of continental shelves that are presently submerged. By a series of direct numerical simulations we investigate the sensitivity of the atmosphere-ocean system to exposure of the extensive Sunda shelf in the western tropical Pacific. We demonstrate that this specific(More)