Andrew B Brown

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BACKGROUND The transcription factor, WT1, is highly overexpressed in malignant pleural mesothelioma (MPM) and immunohistochemical stains for WT1 are used routinely to aid in its diagnosis. Using computer prediction analysis we designed analog peptides derived from WT1 sequences by substituting amino acids at key HLA-A0201 binding positions. We tested the(More)
PURPOSE To establish the safety, maximum tolerated dose (MTD), recommended phase II dose, and preliminary antitumor activity of obatoclax mesylate (GX15-070MS), a Bcl-2 antagonist, in combination with topotecan in patients with solid tumor malignancies. PATIENTS AND METHODS Patients with solid tumor malignancies for whom topotecan was an appropriate(More)
INTRODUCTION We previously reported data on the safety, tolerability, and recommended phase II dose of obatoclax mesylate in conjunction with topotecan in patients with advanced solid tumor malignancies. Preliminary efficacy data suggested activity in patients with recurrent small cell lung cancer (SCLC). Based on these data, we performed a phase II study(More)
In accordance with Section 1769 ofthe California Energy Commission Siting Regulations, Los Esteros Critical Energy Facility, LLC submits the attached Petition to Amend the Commission Decision in this proceeding. Per your instructions, we are enclosing ten (10) hard copies of the Amendment and five (5) CDs. If you have any questions regarding this submittal(More)
Maximal oxygen consumption ((Equation is included in full-text article.)) can be determined through multiple exercise modalities intended to elicit an individual's maximal aerobic exertion. Uphill treadmill running is considered the best modality for measuring (Equation is included in full-text article.). Previous studies have examined correlations between(More)
BACKGROUND GD2/GM2 synthase is a key enzyme in the synthesis of GD2 and GM2 gangliosides found on the surface of neuroblastoma and small cell lung carcinoma (SCLC) cells. In neuroblastoma, persistent levels of GD2/GM2 synthase RNA in bone marrow (BM) following therapy portend poorer progression-free and overall survival. We conducted this study to determine(More)
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