Andrew Arnold

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Many ranking models have been proposed in information retrieval, and recently machine learning techniques have also been applied to ranking model construction. Most of the existing methods do not take into consideration the fact that significant differences exist between queries, and only resort to a single function in ranking of documents. In this paper,(More)
The problem of transfer learning, where information gained in one learning task is used to improve performance in another related task, is an important new area of research. While previous work has studied the supervised version of this problem, we study the more challenging case of unsupervised transductive transfer learning, where no labeled data from the(More)
CONTEXT Experimental and epidemiological data suggest that vitamin E supplementation may prevent cancer and cardiovascular events. Clinical trials have generally failed to confirm benefits, possibly due to their relatively short duration. OBJECTIVE To evaluate whether long-term supplementation with vitamin E decreases the risk of cancer, cancer death, and(More)
Taking a perspective on available evidence that emphasizes relevance to human disease, cyclin D1 is solidly established as an oncogene with an important pathogenetic role in breast cancer and other human tumors. However, the precise cellular mechanisms through which aberrant cyclin D1 expression drives human neoplasia are less well established. Indeed,(More)
BACKGROUND We looked for mutations of the HRPT2 gene, which encodes the parafibromin protein, in sporadic parathyroid carcinoma because germ-line inactivating HRPT2 mutations have been found in a type of familial hyperparathyroidism--hyperparathyroidism-jaw tumor (HPT-JT) syndrome--that carries an increased risk of parathyroid cancer. METHODS We directly(More)
In this paper we explore the usefulness of various types of publication-related metadata, such as citation networks and curated databases, for the task of identifying genes in academic biomedical publications. Specifically, we examine whether knowing something about which genes an author has previously written about, combined with information about previous(More)
PURPOSE In a pivotal phase III trial, the addition of trastuzumab to chemotherapy significantly improved response rate, time to disease progression, and overall survival in women with HER2 overexpressing metastatic breast cancer. We conducted an extension study to this trial to obtain additional safety information and to provide trastuzumab following(More)
The importance of fibroblast growth factor 23 (FGF-23) in the pathogenesis of phosphate wasting disorders has been established, but controversy remains about how parathyroid hormone (PTH), which also stimulates urinary phosphate excretion, regulates the circulating level of FGF-23. We found that the serum FGF-23 concentration was higher in PTH-cyclin D1(More)