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The mitochondrial uniporter is a highly selective calcium channel in the organelle's inner membrane. Its molecular components include the EF-hand-containing calcium-binding proteins mitochondrial calcium uptake 1 (MICU1) and MICU2 and the pore-forming subunit mitochondrial calcium uniporter (MCU). We sought to achieve a full molecular characterization of(More)
Mitochondrial calcium uptake is present in nearly all vertebrate tissues and is believed to be critical in shaping calcium signaling, regulating ATP synthesis and controlling cell death. Calcium uptake occurs through a channel called the uniporter that resides in the inner mitochondrial membrane. Recently, we used comparative genomics to identify MICU1 and(More)
The behavioral effect of single administration of +/- 3,4-methylene-dioxymethamphetamine (MDMA) on rats performing on the differential-reinforcement-of-low-rate 72-second schedule (DRL 72-sec) was compared before and after a period of repeated administration of MDMA known to deplete 5-hydroxytryptamine (5-HT) levels in the brain. Single administration of(More)
Effective approximations are developed for the blocking probability in a general stationary loss model, where key independence and exponential-distribution assumptions are relaxed, giving special attention to dependence among successive service times, not studied before. The new approximations exploit heavy-traffic limits for the steady-state number of busy(More)
Previous work in this laboratory has suggested that antagonist action of 5-hydroxytryptamine2 (5-HT2) receptors and agonist action of 5-HT1 receptors results in antidepressant-like effects (increased reinforcement rate and decreased response rate) in rats performing under the differential-reinforcement-of-low-rate 72-sec schedule (DRL 72-s) of(More)
The effects of eleven 5-hydroxytryptamine antagonists with varying selectivity for the 5-hydroxytryptamine2 (5-HT2) relative to the 5-HT1 binding site were assessed in rats responding under a differential-reinforcement-of-low rate 72-sec (DRL 72-s) schedule of reinforcement. Three drugs with a 1000-fold selectivity for the 5-HT2 binding site (ketanserin,(More)
Trazodone is an atypical antidepressant drug (i.e. blocks neither monoamine uptake nor monoamine oxidase) which tests as an antidepressant drug on the differential-reinforcement-of-low-rate 72-s (DRL 72-s) schedule of reinforcement by increasing the reinforcement rate and decreasing the response rate. m-Chlorophenylpiperazine (m-CPP) is a 5-HT1B and 5-HT1C(More)
(+)-Oxaprotiline (1.25-10 mg/kg), a highly selective and stereospecifically acting norepinephrine (NE) uptake inhibiting drug, increased the reinforcement rate, decreased the response rate, and enhanced temporal discrimination in rats performing under a differential-reinforcement-of-low-rate 72-s schedule of reinforcement similar to other antidepressant(More)
Caffeine and PD 116,600 were found to decrease the reinforcement rate and increase the response rate in rats performing under a differential-reinforcement-of-low rate 72-s (DRL 72-s) schedule of reinforcement. In contrast, antidepressant drugs previously have been found to increase the reinforcement and decrease the response rate. Caffeine has been found to(More)
Effective approximations are developed for the blocking probability in a general stationary loss model with dependence among successive service times as well as among successive interarrival times by exploiting heavy-traffic limits for the steady-state number of busy servers in the associated infinite-server model with the same arrival and service(More)