Andrew A. Li

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The mitochondrial uniporter is a highly selective calcium channel in the organelle's inner membrane. Its molecular components include the EF-hand-containing calcium-binding proteins mitochondrial calcium uptake 1 (MICU1) and MICU2 and the pore-forming subunit mitochondrial calcium uniporter (MCU). We sought to achieve a full molecular characterization of(More)
Mitochondrial calcium uptake is present in nearly all vertebrate tissues and is believed to be critical in shaping calcium signaling, regulating ATP synthesis and controlling cell death. Calcium uptake occurs through a channel called the uniporter that resides in the inner mitochondrial membrane. Recently, we used comparative genomics to identify MICU1 and(More)
Effective approximations are developed for the blocking probability in a general stationary loss model, where key independence and exponential-distribution assumptions are relaxed, giving special attention to dependence among successive service times, not studied before. The new approximations exploit heavy-traffic limits for the steady-state number of busy(More)
Effective approximations are developed for the blocking probability in a general stationary loss model with dependence among successive service times as well as among successive interarrival times by exploiting heavy-traffic limits for the steady-state number of busy servers in the associated infinite-server model with the same arrival and service(More)
The use of virtualized cloud infrastructure has transformed the nature and scope of enterprise computing. A salient challenge for cloud users today is to minimize the cost of completing computational tasks, and the recent introduction of market-driven pricing by major cloud providers such as Amazon and Google only intensifies the potential for cost savings(More)
We consider the class of trees for which all vertices of degree at least 3 lie on a single induced path of the tree. For such trees, a new superposition principle is proposed to generate all possible orderedmultiplicity lists for the eigenvalues of symmetric (Hermitian)matrices whose graph is such a tree. It is shown that no multiplicity lists other than(More)
*Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California; Division of Gastroenterology and Hepatology, University of Tennessee Health Science Center, Memphis, Tennessee; Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois; kSimmons Transplant Institute, Baylor All Saints(More)
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