BACKGROUND Complex biological processes such as acute inflammation induced by trauma/hemorrhagic shock/ (T/HS) are dynamic and multi-dimensional. We utilized multiplexing cytokine analysis coupled with data-driven modeling to gain a systems perspective into T/HS. METHODOLOGY/PRINCIPAL FINDINGS Mice were subjected to surgical cannulation trauma (ST) ±… (More)
SSTA has received a considerable amount of attention in recent years. However, it is a general rule that any approach can only be as accurate as the underlying models. Thus, variation models are an important research topic, in addition to the development of statistical timing tools. These models attempt to predict fluctuations in parameters like doping… (More)
Integrating Directed Self Assembly (DSA) and Multiple Patterning (MP) is an attractive option for printing contact and via layers for sub-7nm process nodes. In the DSA-MP hybrid process, an optimized decomposition algorithm is required to perform the MP mask assignment while considering the DSA advantages and limitations. In this paper, we present an… (More)
Background: Trauma/hemorrhagic shock (T/HS) results in cytokine-mediated acute inflammation that is generally considered detrimental.
Modern CMOS technologies employ process-induced stress to improve carrier mobility and increase drive current. This stress has been shown to be strongly layout dependent; however there is a lack of physical models relating potential performance variation to critical layout parameters. This paper presents compact <i>closed-form</i> models that capture the… (More)
One of the UN sustainable development goals is to achieve universal access to safe and affordable drinking water by 2030. It is locations like Kathmandu, Nepal, a densely populated city in South Asia with endemic typhoid fever, where this goal is most pertinent. Aiming to understand the public health implications of water quality in Kathmandu we subjected… (More)