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BACKGROUND Bacterial vaginosis (BV) is the most common vaginal disorder of reproductive-age women. Yet the cause of BV has not been established. To uncover key determinants of BV, we employed a multi-omic, systems-biology approach, including both deep 16S rRNA gene-based sequencing and metabolomics of lavage samples from 36 women. These women varied(More)
—The trend to integrate multiple functionalities on the same (off-the-shelf) hardware has made the selection of the right scheduling algorithm and configuration difficult. This selection requires the designer to validate any scheduling decision already during early design steps on the target architecture, e.g., by using a reconfigurable scheduling framework(More)
BACKGROUND HLA-DRB1 0401 is associated with susceptibility, while HLA-DRB1 0402 is associated with resistance to developing rheumatoid arthritis (RA) and collagen-induced arthritis in humans and transgenic mice respectively. The influence of gut-joint axis has been suggested in RA, though not yet proven. METHODOLOGY/PRINCIPAL FINDINGS We have used HLA(More)
Rheumatoid arthritis (RA) is a multifactorial disease and requires interaction between genetic and environmental factors for predisposition. The presence of bacterial DNA of the gut residing commensals in synovium as well as dysbiosis of certain commensal bacteria in faecal samples of RA patients as compared to controls suggest a significant role of the gut(More)
—Multicore systems are being increasingly used for embedded system deployments, even in safety-critical domains. Co-hosting applications of different criticality levels in the same platform requires sufficient isolation among them, which has given rise to the mixed-criticality scheduling problem and several recently proposed policies. Such policies(More)
Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc). Parkinsonian patients and animal models of PD show inflammatory phenomena such as microglial activation and cytokine production that could modulate the progression of the disease, since they play a crucial role in the degenerative(More)
—Energy harvesting is generally seen to be the key to power cyber-physical systems in a low-cost, long term, efficient manner. However, harvesting has traditionally been coupled with large energy storage devices to mitigate the effects of the source's variability. The emerging class of transiently powered systems avoids this issue by performing computation(More)
BACKGROUND The human gut microbiota interacts closely with human diet and physiology. To better understand the mechanisms behind this relationship, gut microbiome research relies on complementing human studies with manipulations of animal models, including non-human primates. However, due to unique aspects of human diet and physiology, it is likely that(More)
The mammalian gastrointestinal (GI) microbiome, which plays indispensable roles in host nutrition and health, is affected by numerous intrinsic and extrinsic factors. Among them, antibiotic (ATB) treatment is reported to have a significant effect on GI microbiome composition in humans and other animals. However, the impact of ATBs on the GI microbiome of(More)