Andres G. Zuleta

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Emerging evidence suggests that mitochondrial (mt) DNA damage may be a trigger for apoptosis in oxidant-challenged pulmonary artery endothelial cells (PAECs). Understanding the rate-limiting determinants of mtDNA repair may point to new targets for intervention in acute lung injury. The base excision repair (BER) pathway is the only pathway for oxidative(More)
Blood flow throughout the vascular circuit exerts a tangential force called shear stress upon all vessel walls. Under homeostatic conditions, shear stress is maintained within a narrow range. It has been shown that an alteration from this normal range of shear stress activates a biochemical signaling cascade in a process termed mechanotransduction. Although(More)
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