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Genome sequencing of large numbers of individuals promises to advance the understanding, treatment, and prevention of human diseases, among other applications. We describe a genome sequencing platform that achieves efficient imaging and low reagent consumption with combinatorial probe anchor ligation chemistry to independently assay each base from patterned(More)
BACKGROUND AND PURPOSE Hyperglycemia is common after subarachnoid hemorrhage (SAH). The extent to which prolonged hyperglycemia contributes to in-hospital complications and poor outcome after SAH is unknown. METHODS We studied an inception cohort of 281 SAH patients with an initial serum glucose level obtained within 3 days of SAH onset and who had at(More)
BACKGROUND AND PURPOSE Vasospasm is an important complication of subarachnoid hemorrhage, but is variably defined in the literature. METHODS We studied 580 patients with subarachnoid hemorrhage and identified those with: (1) symptomatic vasospasm, defined as clinical deterioration deemed secondary to vasospasm after other causes were eliminated; (2)(More)
INTRODUCTION Predicting outcome in patients with poor-grade subarachnoid hemorrhage (SAH) may help guide therapy and assist in family discussions. The objective of this study was to determine if continuous electroencephalogram (cEEG) monitoring results are predictive of 3-month outcome in critically ill patients with SAH. METHODS We prospectively studied(More)
In this paper we first develop two statistical tests of the null hypothesis that early release data are rational. The tests are consistent against generic nonlinear alternatives, and are conditional moment type tests, in the spirit of We then use this test, in conjunction with standard regression analysis in order to individually and jointly analyze a(More)
We thank Javier Caicedo for providing excellent research assistance in the construction of this dataset described in this paper. The information and opinions presented in this work are entirely those of the authors, and express or imply no endorsement by the Inter-American Development Bank, the International Monetary Fund, the Board of Executive Directors(More)
INTRODUCTION Seizures refractory to third-line therapy are also labeled super-refractory status epilepticus (SRSE). These seizures are extremely difficult to control and associated with poor outcome. We aimed to characterize efficacy and side-effects of continuous infusions of pentobarbital (cIV-PTB) treating SRSE. METHODS We retrospectively reviewed(More)
A growing theoretical literature advocates the use of countercyclical capital control policy, that is, the tightening of restrictions on net capital inflows during booms and the relaxation thereof during recessions. We examine the behavior of capital controls in 78 countries over the period 1995-2011. We find that capital controls are remarkably acyclical.(More)
OBJECTIVE To identify risk factors for refractory fever after subarachnoid hemorrhage (SAH), and to determine the impact of temperature elevation on outcome. METHODS We studied a consecutive cohort of 353 patients with SAH with a maximum daily temperature (T(max)) recorded on at least 7 days between SAH days 0 and 10. Fever (>38.3 degrees C) was routinely(More)
OBJECT The authors sought to determine frequency, risk factors, and impact on outcome of asymptomatic cerebral infarction due to vasospasm after subarachnoid hemorrhage (SAH). METHODS The authors prospectively studied 580 patients with SAH admitted to their center between July 1996 and May 2002. Delayed cerebral ischemia (DCI) from vasospasm was defined(More)