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A unique form of lactate dehydrogenase was observed in the starch-gel electrophoretic patterns of adult human testes. It was present in sperm, but absent in prepubertal testes. Its electrophoretic mobility, heat stability, kinetic behavior with pyridine nucleotide analogs, and chromatographic characteristics on diethylaminoethyl cellulose were intermediate(More)
Cellular differentiation involves profound remodelling of chromatic landscapes, yet the mechanisms by which somatic cell identity is subsequently maintained remain incompletely understood. To further elucidate regulatory pathways that safeguard the somatic state, we performed two comprehensive RNA interference (RNAi) screens targeting chromatin factors(More)
Fragile X syndrome, a common form of inherited intellectual disability, is caused by loss of the fragile X mental retardation protein FMRP. FMRP is present predominantly in the cytoplasm, where it regulates translation of proteins that are important for synaptic function. We identify FMRP as a chromatin-binding protein that functions in the DNA damage(More)
Electrophoretic resolution of lactate dehydrogenase in mature testes from a variety of animals revealed one or more unusual isozymes in addition to the usual five forms. Dissociation of the enzyme and recombination of the polypeptide subunits led to the formation of new isozymes and to a redistribution of activity among those normally present, indicating(More)
Homogenates of pigeon testes show three types of lactate dehydrogenase isozyme patterns. Recombination of the polypeptide subunits of the dehydrogenase in mixtures of the different types, and the distribution of the three isozyme patterns in six different pigeon populations demonstrated that lactate dehydrogenase synthesis in pigeon testes is under the(More)
—Because wireless microsystems can only incorporate tiny batteries, they typically exhaust stored on-board energy quickly. Fortunately, harvesting ambient energy is a viable means of extending their operational lifetimes, except starting and restarting miniaturized microwatt harvesters from no-charge conditions is difficult. The challenge is drawing usable(More)