Andrelina Noronha Coelho-de-Souza

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The effects of methyleugenol (ME) on guinea-pig isolated ileum were studied. ME reversibly relaxed basal tonus (EC50 of 52.2 +/- 18.3 microM), an action unaltered by 0.5 microM tetrodotoxin or 0.5 mM hexamethonium, and relaxed the ileum pre-contracted with 60 mM KCl. ME slightly hyperpolarized the ileum from -57.3 to -62.8 mV but had no effect in(More)
1. 1,8-Cineole is a non-toxic small terpenoid oxide believed to have medicinal properties in folk medicine. It has been shown to have various pharmacological effects, including blockade of the compound action potential (AP). In the present study, using intracellular recording techniques, we investigated the effects of 1,8-cineole on the electrophysiological(More)
The effects of eugenol on the excitation-contraction coupling of the toad (Bufo paracnemis) sartorius were studied. Eugenol (0.1-2.5 mM) blocked the contracture induced by 80 mM K+. At 2.5 mM, it decreased the depolarization, induced by 80 mM K+, by 14 mV. This is not sufficient to explain the complete blockade of the potassium contracture. At higher(More)
Various essential oils are rich in carvacrol, a monoterpenic phenol isomeric with thymol. This study was undertaken to assess the vasorelaxant effects of thymol and carvacrol in rat isolated aorta and the putative mechanisms underlying these effects. Thymol and carvacrol produced a concentration-dependent relaxation on the aortic ring preparations(More)
This study was undertaken to assess the effects of eugenol (EUG) on tracheal muscle (TM) and the putative mechanisms underlying these effects. Cumulatively increasing concentrations (1-1000 μm) of EUG did not affect the resting tonus of TM. However, EUG (1-2000 μm) reduced the contractions induced by electrical field stimulation (IC(50) = 842.3 ± 52.7 μm),(More)
BACKGROUND Anethole and estragole are monoterpene position isomers and constituents of essential oils from aromatic plants and were used in this study with the aim of analyzing their anti-inflammatory activity. METHODS The anti-edematogenic effects of anethole and estragole were evaluated through plethysmometry in Swiss mice. RESULTS Anethole inhibited(More)
Croton zehntneri is an aromatic plant native to Northeastern Brazil, where it is often used in folk medicine. In the present study the antinociceptive effects of the essential oil of Croton zehntneri (EOCz) were evaluated in mice. EOCz administered orally at doses of 100 and 300 mg/kg reduced paw licking time in the second phase of the formalin test from(More)
Croton nepetaefolius Baill., is an aromatic plant native to the northeast of Brazil where it is extensively used in folk medicine as a sedative, orexigen and antispasmodic agent. In the present study the antinociceptive effects of the essential oil of C. nepetaefolius (EOCn), administered orally, were evaluated in male Swiss mice (20-25 g). In the acetic(More)
Plants of the genus Croton have been used extensively in the northeast of Brazil for treating various clinical conditions. Previous studies have demonstrated that the essential oil of some specimens of Croton sp. have a relaxing effect on tracheal smooth muscle. Our study aimed to characterize the effects of Croton sonderianus essential oil samples,(More)
Cardiovascular effects of intravenous (i.v.) treatment with the essential oil of Croton nepetaefolius (EOCN) were investigated in rats. Additionally, this study examined the importance of the autonomic nervous system in mediation of the EOCN-induced changes in mean aortic pressure (MAP) and heart rate (HR). In both pentobarbitone-anaesthetised and conscious(More)