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Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases
Abstract Atherosclerosis is a life-long illness that begins with risk factors, which in turn contribute to the development of subclinical disease, followed by the establishment of overtExpand
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Toxicity of pristine versus functionalized fullerenes: mechanisms of cell damage and the role of oxidative stress
The fullerene C60, due to the physicochemical properties of its spherical cage-like molecule build exclusively from carbon atoms, is able to both scavenge and generate reactive oxygen species. WhileExpand
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Involvement of ERK1/2 Kinase in Insulin-and Thrombin-Stimulated Vascular Smooth Muscle Cell Proliferation
It is well recognized that the proliferation of vascular smooth muscle cells (VSMCs) is a key event in the pathogenesis of various vascular diseases, including atherosclerosis and hypertension. WeExpand
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Oxidative stress-mediated hemolytic activity of solvent exchange-prepared fullerene (C60) nanoparticles.
The present study investigated the hemolytic properties of fullerene (C(60)) nanoparticles prepared by solvent exchange using tetrahydrofuran (nC(60)THF), or by mechanochemically assistedExpand
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Endothelial dysfunction in dyslipidaemia: Molecular mechanisms and clinical implications.
The endothelium consists of a monolayer of endothelial cells (ECs) which form the inner cellular lining of veins, arteries, capillaries and lymphatic vessels. ECs interact with the blood and lymph.Expand
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Interrelatedness between C-reactive protein and oxidized low-density lipoprotein
Abstract C-reactive protein (CRP) is a marker of inflammation. Atherosclerosis is now recognized as inflammatory disease, and it seems that CRP directly contributes to atherogenesis. Oxidation ofExpand
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A novel hypothesis regarding the possible involvement of cytosolic phospholipase 2 in insulin‐stimulated proliferation of vascular smooth muscle cells
Insulin (INS) via INS receptor acts as a mitogen in vascular smooth muscle cells (VSMCs) through stimulation of multiple signaling mechanisms, including p42/44 mitogen‐activated protein kinaseExpand
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Chronic hepatitis C, insulin resistance and vascular disease.
The role of hepatitis C virus (HCV) infection in the development of vascular disease is controversial. Insulin resistance (IR) is a recognized risk factor for cardiovascular disease (CVD) and isExpand
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Role of PI3K/AKT, cPLA2 and ERK1/2 signaling pathways in insulin regulation of vascular smooth muscle cells proliferation.
Vascular smooth muscle cells (VSMCs) respond to arterial wall injury by intimal proliferation and play a key role in atherogenesis by proliferating and migrating excessively in response to repeatedExpand
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Insulin, thrombine, ERK1/2 kinase and vascular smooth muscle cells proliferation.
Vascular smooth muscle cells (VSMC) respond to arterial wall injury by intimal proliferation and play a key role in atherogenesis by proliferating and migrating excessively in response to repeatedExpand
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