• Publications
  • Influence
Multiple sequence-specific factors generate the nucleosome-depleted region on CLN2 promoter.
Nucleosome-depleted regions (NDRs) are ubiquitous on eukaryotic promoters. The formation of many NDRs cannot be readily explained by previously proposed mechanisms. Here, we carry out a focused studyExpand
  • 85
  • 12
  • PDF
The CDK-APC/C Oscillator Predominantly Entrains Periodic Cell-Cycle Transcription
Throughout cell-cycle progression, the expression of multiple transcripts oscillate, and whether these are under the centralized control of the CDK-APC/C proteins or can be driven by a de-centralizedExpand
  • 44
  • 8
  • PDF
Pathological mutations H187R and E196K facilitate subdomain separation and prion protein conversion by destabilization of the native structure
The mechanism of prion protein (PrP) conversion, the key event in prion diseases, is still not understood. We investigated how perturbations of interactions between the subdomains β1‐α1‐β2 and α2‐α3Expand
  • 12
Effect of Hydrophobic Mutations in the H2-H3 Subdomain of Prion Protein on Stability and Conversion In Vitro and In Vivo
Prion diseases are fatal neurodegenerative diseases, which can be acquired, sporadic or genetic, the latter being linked to mutations in the gene encoding prion protein. We have recently describedExpand
  • 9
  • PDF
A unicellular relative of animals generates a layer of polarized cells by actomyosin-dependent cellularization
In animals, cellularization of a coenocyte is a specialized form of cytokinesis that results in the formation of a polarized epithelium during early embryonic development. It is characterized byExpand
  • 9
A Unicellular Relative of Animals Generates an Epithelium-Like Cell Layer by Actomyosin-dependent Cellularization
In animals, cellularization of a coenocyte is a specialized form of cytokinesis that results in the formation of a polarized epithelium during early embryonic development. It is characterized byExpand
  • 3
Decoupling of Nuclear Division Cycles and Cell Size during the Coenocytic Growth of the Ichthyosporean Sphaeroforma arctica
Summary Coordination of the cell division cycle with the growth of the cell is critical to achieve cell size homeostasis [1]. Mechanisms coupling the cell division cycle with cell growth have beenExpand
  • 4
An APC/C-Cdh1 Biosensor Reveals the Dynamics of Cdh1 Inactivation at the G1/S Transition
B-type cyclin-dependent kinase activity must be turned off for mitotic exit and G1 stabilization. B-type cyclin degradation is mediated by the anaphase-promoting complex/cyclosome (APC/C); during andExpand
  • 4
  • PDF
Cell cycle transcriptomics of Capsaspora provides insights into the evolution of cyclin-CDK machinery
Progression through the cell cycle in eukaryotes is regulated on multiple levels. The main driver of the cell cycle progression is the periodic activity of cyclin-dependent kinase (CDK) complexes. InExpand
  • 1
  • PDF
Gradual evolution of cell cycle regulation by cyclin-dependent kinases during the transition to animal multicellularity
Progression through the cell cycle in eukaryotes is regulated on multiple levels. The main driver of the cell cycle progression is the periodic activity of cyclin-dependent kinase (CDK) complexes. InExpand