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Cytosolic Proteostasis via Importing of Misfolded Proteins into Mitochondria
It is shown that, in yeast, cytosolic proteins prone to aggregation are imported into mitochondria for degradation and this mitochondria-mediated proteostasis mechanism MAGIC (mitochondria as guardian in cytosol) is named and evidence that it may exist in human cells is provided.
Actin depolymerization drives actomyosin ring contraction during budding yeast cytokinesis.
Cytosolic proteostasis through importing of misfolded proteins into mitochondria
Targeting the Adaptability of Heterogeneous Aneuploids
Hypo-Osmotic-Like Stress Underlies General Cellular Defects of Aneuploidy
A common aneuploidy gene-expression signature is identified in yeast that is suggestive of hypo-osmotic stress, and which leads to cells that exhibit increased plasma-membrane stress and impaired endocytosis.
The Probabilistic Fault Tolerance of Neural Networks in the Continuous Limit
This paper addresses the fundamental question of the impact of the crash of a random subset of neurons on the overall computation of a neural network and the error in the output it produces and designs an algorithm achieving fault tolerance using a reasonable number of neurons.
Predicting complex genetic phenotypes using error propagation in weighted networks
- El Mahdi El Mhamdi, Andrei Kucharavy, R. Guerraoui, Rong Li
- Computer Science, Biology
- 21 December 2018
This work investigates if biological networks could be approximated as overlapping, feed-forward networks where the nodes have non-linear activation functions and predicts that biological networks might be better understood as a distributed system, comprising potentially unreliable components.
Robustness and evolvability of heterogeneous cell populations
A general mathematical model is developed that predicts that robustness is, in fact, essential for evolvability, especially for more adverse environments, a trend the authors observe in aneuploid budding yeast and breast cancer cells.
On the Transcriptomic Signature and General Stress State Associated with Aneuploidy
In this short article, which has been submitted to PNAS as a Letter to the Editor, major concerns about Terhorst et al. are explained and why the previous conclusion stands valid.
Molecular mechanisms of aneuploidy-mediated stress-resistance
- Andrei Kucharavy
- 8 December 2017
A general mathematical model of organism adaptation to adverse environments, and a predictive model for inferring most likely pathways underlying the phenotype of large-scale genetic perturbations is developed.