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  • Andrei Chabes, Bilyana Georgieva, Vladimir Domkin, Xiaolan Zhao, Rodney Rothstein, Lars Thelander
  • Biology, Medicine
  • Cell
  • 2003 (First Publication: 1 February 2003)
  • In eukaryotes, DNA damage elicits a multifaceted response that includes cell cycle arrest, transcriptional activation of DNA repair genes, and, in multicellular organisms, apoptosis. We demonstrateExpand
  • Xudong Zhao, Andrei Chabes, Vladimir Domkin, Lars Thelander, Rodney Rothstein
  • Biology, Medicine
  • The EMBO journal
  • 2001 (First Publication: 2 July 2001)
  • The evolutionarily conserved protein kinases Mec1 and Rad53 are required for checkpoint response and growth. Here we show that their role in growth is to remove the ribonucleotide reductase inhibitorExpand
  • Andrei Chabes, Bruce W. Stillman
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2007 (First Publication: 23 January 2007)
  • In eukaryotic cells the concentration of dNTP is highest in S phase and lowest in G1 phase and is controlled by ribonucleotide reductase (RNR). RNR activity is eliminated in all eukaryotes in G1Expand
  • Xudong Zhao, Bilyana Georgieva, +6 authors Rodney Rothstein
  • Medicine, Biology
  • Molecular and Cellular Biology
  • 2000 (First Publication: 1 December 2000)
  • ABSTRACT In budding yeast, MEC1 and RAD53 are essential for cell growth. Previously we reported that mec1or rad53 lethality is suppressed by removal of Sml1, a protein that binds to the large subunitExpand