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B-NK is a C-type lectin with an immunorecptor tyrosine-based inhibition motif, that is located in the vicinity of the chicken MHC and that has been described as a potential chicken NK cell receptor. We have generated an epitope tagged B-NK version for immunization and for biochemical studies. B-NK was expressed as a heavily glycosylated, homodimeric, type(More)
CUB-domain-containing protein 1 (CDCP1) is an integral membrane glycoprotein with potential as a marker and therapeutic target for a number of cancers. Here we examine mechanisms regulating cellular processing of CDCP1. By analyzing cell lines exclusively passaged non-enzymatically and through use of a panel of protease inhibitors, we demonstrate that(More)
Software development for Cyber-Physical Systems (CPS) is a sophisticated activity as these systems are inherently complex. The engineering of CPS requires composition and interaction of diverse distributed software modules. Describing both, a system's architecture and behavior in integrated models, yields many advantages to cope with this complexity: the(More)
We sought to identify fibroblast growth factor receptor 2 (FGFR2) kinase domain mutations that confer resistance to the pan-FGFR inhibitor, dovitinib, and explore the mechanism of action of the drug-resistant mutations. We cultured BaF3 cells overexpressing FGFR2 in high concentrations of dovitinib and identified 14 dovitinib-resistant mutations, including(More)
Effective model-driven engineering of complex systems requires to appropriately describe different specific system aspects. To this end, efficient integration of different heterogeneous modeling languages is essential. Modeling language integaration is onerous and requires in-depth conceptual and technical knowledge and effort. Traditional modeling lanugage(More)
Engineering software for robotics applications requires multi-domain and application-specific solutions. Model-driven engineering and modeling language integration provide means for developing specialized, yet reusable models of robotics software architectures. Code generators transform these platform independent models into executable code specific to(More)
Component-based software engineering aims to reduce software development effort by reusing established components as building blocks of complex systems. Defining components in general-purpose programming languages restricts their reuse to platforms supporting these languages and complicates component composition with implementation details. The vision of(More)
In the last few years dysregulated expression of the cell surface glycoprotein CUB domain-containing protein 1 (CDCP1) has been associated with several cancers and this cell surface molecule has been recognized both as a tumor marker and as a potential target to disrupt progression of cancer. Here we summarize what is known about CDCP1 including its(More)
Genetic vaccination with adenoviral (Ad) gene transfer vectors requires transduction of professional antigen-presenting cells. However, because the natural Ad receptors are expressed on many cell types, the Ad vectors currently in use are characterized by high promiscuity. In fact, the majority of injected Ad vector particles are likely to transduce(More)