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sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers
TLDR
CSF sTREM2 levels are increased in the early symptomatic phase of AD, probably reflecting a corresponding change of the microglia activation status in response to neuronal degeneration.
The ERICA Score: An MR Imaging-based Visual Scoring System for the Assessment of Entorhinal Cortex Atrophy in Alzheimer Disease.
TLDR
An ERICA score of 2 or greater indicates probable AD with high diagnostic accuracy, as the entorhinal cortex is one of the first brain structures affected in Alzheimer disease (AD).
Real-life gait assessment in degenerative cerebellar ataxia
TLDR
This study provides Class I evidence that a set of gait variability measures, even if accessed in real life, correlated with the clinical severity of ataxia in patients with degenerative cerebellar disease.
Natural History, Phenotypic Spectrum, and Discriminative Features of Multisystemic RFC1 Disease
TLDR
This study provides Class II evidence that RFC1 repeat expansions are associated with CANVAS and ACC, with RFC1 disease occurring across continents and as variable, overlapping clusters along a continuous multisystemic disease spectrum, including MSA-C-overlap.
Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer’s disease
TLDR
Cerebrospinal fluid levels of C-reactive protein and soluble TREM2 differed between nondemented subjects, patients with mild cognitive impairment [MCI], or patients with AD and were associated with amyloid and tau pathology.
Clinico‐Genetic, Imaging and Molecular Delineation of COQ8A ‐Ataxia: A Multicenter Study of 59 Patients
TLDR
The clinicogenetic, molecular, and neuroimaging spectrum of COQ8A‐ataxia in a large worldwide cohort is mapped, and first progression data is provided, including treatment response to coenzyme Q10 (CoQ10).
Defining diagnostic cutoffs in neurological patients for serum very long chain fatty acids (VLCFA) in genetically confirmed X-Adrenoleukodystrophy
TLDR
The objective of this study was to define optimal serum VLCFA cutoff values in patients with X-ald-like phenotypes for the differentiation of genetically confirmed X-ALD and Non-X-ALD individuals, and to suggest using new optimized cutoff values, especially the two ratios, in combination with standard lipid profiles.
Transient activity in monkey area MT represents speed changes and is correlated with human behavioral performance.
TLDR
The measured neuronal representation of a wide range of positive and negative speed changes in area MT of fixating macaques and its close correlation with behavioral measures of speed change detection suggest that neuronal transients in areaMT facilitate the detection of rapid changes in visual input.
Reduction of microbleeds by immunosuppression in a patient with Aβ-related vascular inflammation
TLDR
Under long-term immunosuppressive treatment, a reduced number of cortical micobleeds was observed on repeat MRIs because of both the prevention of new microbleeds and the clearance of those existing at baseline.
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