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Development from inoculated sporozoites to unsporulated oocysts of Isospora suis Biester, 1934 is described in a swine testicular (ST) cell line. Sporozoites penetrated ST cells within 1 hr postinoculation (PI). Development was initially by endodyogeny to produce binucleate type I meronts and type I merozoites. Division by endodyogeny continued during the(More)
Platelet-activating factor (PAF) has been called an important mediator of cardiovascular shock due to immunological reactions including anaphylaxis and endotoxic reactions. According to previous reports, PAF dose-dependently decreases ventricular contractility and coronary flow rates. Diverse mechanisms of the PAF-induced cardiodepressive effects have been(More)
Pancreatic cancer is characterized by a microenvironment suppressing immune responses. RIG-I-like helicases (RLH) are immunoreceptors for viral RNA that induce an antiviral response program via the production of type I interferons (IFN) and apoptosis in susceptible cells. We recently identified RLH as therapeutic targets of pancreatic cancer for(More)
Neutral proteases (elastase, cathepsin G and cathepsin B1) from human leukocytes were isolated and the dose-dependent influence of glycosaminoglycanpolysulfate (GAGPS, Luitpoldwerke München) on the activity of these enzymes was tested using chromogenic substrates. The inhibition of elastase up to 70 %. (as reported in the literature) could be confirmed,(More)
Human high molecular weight (HMW) kininogen was purified by chromatography on DEAE-Sephadex A-50 and CM-Sephadex C-50, followed by gel filtration on Sephadex G-50. From 5 l fresh human plasma approximately 120 mg HMW kininogen was obtained. The yield was 40%. The preparation had a specific activity of 14 microgram bradykinin equivalent/A280 unit. Upon(More)
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