Andreas Spaeth

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Previous work has demonstrated a continuous release of citrulline from the small intestine into the circulation. To evaluate the physiologic significance of this process, we have now measured citrulline uptake and release by isolated, perfused livers and, through surgical means and arteriovenous difference measurements, by various organs of the rat in vivo.(More)
Only a small fraction of the L-[U-14Clglutamate (2%) and the L-[U-14Clglutamine (34%) administered at a 6 rnrw concentration into the lumen of rat jejunal segments in situ was recovered unchanged in venous blood collected from the segments. The remaining 14C of both amino acids was recovered in the blood as CO, (60%), proline (5%), citrulline (4%), alanine(More)
Studies using rat livers perfused with recycled, serum-containing medium plus [3H]leucine revealed that secreted VLDL contain three forms of apolipoprotein B (apoB), B-48, B-95, and B-100, all synthesized by the liver. The B-48/(B-95 + B-100) [3H]leucine incorporation ratio ranged from 0.22 to 3.25 with livers of rats fed different diets, and the ratio was(More)
Photodynamic inactivation of bacteria (PIB) by efficient singlet oxygen photosensitizers might be a beneficial alternative to antibiotics in the struggle against multiresistant bacteria. Phenothiazinium dyes belong to the most prominent classes of such sensitizers due to their intense absorption in the red-light region (λ(abs, max) ca. 600-680 nm, ε >(More)
From measurements of tritium incorporation following the perfusion in situ of livers with blood enriched in 3HZ0, the rate of hepatic fatty acid and cholesterol biosynthesis in young nonfasted rats was found to be 7.0 and 0.09 pmoles per g of liver per hour, respectively. Newly synthesized fatty acids were utilized by liver in the same manner as has been(More)
Increasing antibiotic resistance is one of the world's greatest health problems. The food chain is an important factor in the transfer of resistant germs from animals to humans. This study focuses on photodynamic inactivation (PDI), employing curcumin bound to polyvinylpyrrolidone (PVP-C) and NovaSol®-curcumin as photosensitizers, as potent tool for the(More)
The aim of this study was to demonstrate that the periodontal pathogen Aggregatibacter actinomycetemcomitans (AA) can be killed by irradiation with blue light derived from a LED light-curing unit due to its endogenous photosensitizers. Planktonic cultures of AA and Escherichia coli were irradiated with blue light from a bluephase® C8 light-curing unit with(More)
Photodynamic inactivation of bacteria (PIB) proves to be an additional method to kill pathogenic bacteria. PIB requires photosensitizer molecules that effectively generate reactive oxygen species like singlet oxygen when exposed to visible light. To allow a broad application in medicine, photosensitizers should be safe when applied in humans. Substances(More)