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In mammals, genome-wide chromatin maps and immunofluorescence studies show that broad domains of repressive histone modifications are present on pericentromeric and telomeric repeats and on the inactive X chromosome. However, only a few autosomal loci such as silent Hox gene clusters have been shown to lie in broad domains of repressive histone(More)
Imprinted macro non-protein-coding (nc) RNAs are cis-repressor transcripts that silence multiple genes in at least three imprinted gene clusters in the mouse genome. Similar macro or long ncRNAs are abundant in the mammalian genome. Here we present the full coding and non-coding transcriptome of two mouse tissues: differentiated ES cells and fetal head(More)
With today's ubiquity of smartphones, tablets and other mobile devices, more and more businesses develop and use mobile applications. Multiple platforms including Android and iOS form the market of mobile devices, so it can be important to be able to deliver software for more than one platform. Vendor-supported SDKs are feature-rich but incompatible with(More)
The most striking characteristic of CHO cells is their adaptability, which enables efficient production of proteins as well as growth under a variety of culture conditions, but also results in genomic and phenotypic instability. To investigate the relative contribution of genomic and epigenetic modifications towards phenotype evolution, comprehensive genome(More)
Recent research on the professionalization of psychology at the end of the nineteenth century shows how objects of knowledge which appear illegitimate to us today shaped the institutionalization of disciplines. The veridical or telepathic hallucination was one of these objects, constituting a field both of division and exchange between nascent psychology(More)
We address the slow convergence and poor stability of quasi-newton sequential quadratic programming (SQP) methods that is observed when solving experimental design problems, in particular when they are large. Our findings suggest that this behavior is due to the fact that these problems often have bad absolute condition numbers. To shed light onto the(More)
OBJECTIVE The objective of this prospective study was to evaluate whether magnetic resonance imaging (MRI) is equivalent to lateral cephalometric radiographs (LCR, "gold standard") in cephalometric analysis. METHODS The applied MRI technique was optimized for short scanning time, high resolution, high contrast and geometric accuracy. Prior to orthodontic(More)
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