Andreas Sebastian Peters

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Wound healing crucially relies on the mechanical activity of fibroblasts responding to TGFβ1 and to forces transmitted across focal adhesions. Integrin-linked kinase (ILK) is a central adapter recruited to integrin β1 tails in focal adhesions mediating the communication between cells and extracellular matrix. Here, we show that fibroblast-restricted(More)
BACKGROUND Absent in melanoma (AIM2) was recently identified to act as a cytosolic DNA sensor in innate immunity. Considering the role of chronic inflammation in atherosclerosis, we hypothesized that AIM2 may act as a damage signal that is activated in response to cellular stress likewise in vascular cells of larger arteries. We thus addressed AIM2(More)
Mechanical forces are highly variable ranging from the ubiquitous gravity force to compression, fluid shear, torsion, tension and other forms. Mechanical forces act on cells and modulate their biological responses by regulating gene transcription, enzyme and growth factor activity. In soft connective tissues, formation of myofibroblasts strictly requires a(More)
A. Peters, M. Schwickert, A. Reiter and C. Dorn, GSI, Darmstadt, Germany Introduction In June 2003 it was decided that the GSI Beam Diagnostics (BD) group would act as contractor for the delivery of beam diagnostic devices for the heavy-ion cancer therapy facility HIT in Heidelberg. The contract included the production of the mechanical parts(More)
Glo1 (glyxoalase I) is a cytosolic protein expressed in all mammalian cells. Its physiological function is the detoxification of MG (methylglyoxal), which is a potent precursor of AGEs (advanced glycation end-products). Although the impact of AGEs on different forms of vascular diseases has been intensively investigated, the evidence for the involvement of(More)
A new type of beam transformer, based on the principle of a Cryogenic Current Comparator (CCC), was built to measure extracted ion beams from the SIS, the heavy ion synchroton at GSI. A current resolution of 0:006 0:065 nA=Hz, depending on the frequency range, could be achieved allowing us to measure ion beams with intensities greater than 10 particles per(More)
OBJECTIVE Glyoxalase 1 (GLO1) is ubiquitously expressed in the cytosol of the cell and is the major opponent against the reactive metabolite methylglyoxal, which is involved in the development of atherosclerosis. Nondiabetic individuals with an increased hemoglobin A1c (HbA1c) level are at higher risk for development of cardiovascular diseases. As such,(More)
Abdominal aortic aneurysm is a common degenerative vascular disorder associated with sudden death due to aortic rupture. This review describes epidemiology, predisposing factors, and biology of ruptured abdominal aortic aneurysms (rAAAs). Based on a selective literature search in Medline (PubMed), original publications, meta-analyses, systematic reviews,(More)
Many tissues are constantly exposed to mechanical stress, e.g. shear stress in vascular endothelium, compression forces in cartilage or tensile strain in the skin. Dermal fibroblasts can differentiate into contractile myofibroblasts in a process requiring the presence of TGFβ1 in addition to mechanical load. We aimed at investigating the effect of cyclic(More)
Das intramurale Hämatom (IMH) zählt mit dem penetrierenden Aortenulkus und der klassischen Aortendissektion zur Entität des akuten Aortensyndroms. Typischerweise präsentiert sich das IMH mit akutem Brust- oder Rückenschmerz. Eine Durchblutungsstörung des Rückenmarks als Initialsymptom eines IMH ist hingegen selten. Wir beschreiben anhand eines Fallberichts(More)