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Towards standardization of RNA quality assessment using user-independent classifiers of microcapillary electrophoresis traces

• Sandrine Imbeaud, Esther Graudens, +6 authors Charles Auffray
• Nucleic acids research
• 2005

While it is universally accepted that intact RNA constitutes the best representation of the steady-state of transcription, there is no gold standard to define RNA quality prior to gene expression… (More)

RNA Integrity Number ( RIN ) – Standardization of RNA Quality Control Application

• Odilo M. Mueller, Samar Lightfoot, Andreas Schroeder
• 2004

The assessment of RNA integrity is a critical first step in obtaining meaningful gene expression data. Using intact RNA is a key element for successful microarray or RT-PCR analyses. The Agilent 2100… (More)

Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver

• Andreas Schroeder, Kathrin Klein, +4 authors Ulrich M. Zanger
• The Pharmacogenomics Journal
• 2013

Expression quantitative trait loci (eQTL) analysis is a powerful approach toward identifying genetic loci associated with quantitative changes in gene expression. We applied genome-wide association… (More)

Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry.

• Philipp Yu, Rainer Constien, +28 authors Geert Cornelius Mudde
• Immunity
• 2005

The identification of specific genetic loci that contribute to inflammatory and autoimmune diseases has proved difficult due to the contribution of multiple interacting genes, the inherent genetic… (More)

Molecular mechanisms of sex determination in reptiles.

• Turk Rhen, Andreas Schroeder
• Sexual development : genetics, molecular biology…
• 2010

Charles Darwin first provided a lucid explanation of how gender differences evolve nearly 140 years ago. Yet, a disconnect remains between his theory of sexual selection and the mechanisms that… (More)

A novel mechanism for target gene-specific SWI/SNF recruitment via the Snf2p N-terminus

• Matthias Weider, Andreas Schroeder, Franz Klebl, Nadja Sauer
• Nucleic acids research
• 2011

Chromatin-remodeling complexes regulate the expression of genes in all eukaryotic genomes. The SWI/SNF complex of Saccharomyces cerevisiae is recruited to its target promoters via interactions with… (More)

Synergistic interaction of two independent genetic loci causes extreme elevation of serum IgA in mice

• Bernd Schneider, Petra Hanke, +5 authors Juergen Laufs
• Genes and Immunity
• 2004

Understanding the molecular regulation of immunoglobulin A (IgA) expression is important as it plays an essential role in the first-line defence through mucosal secretions. Using inbred mouse… (More)

Distinct transcriptional changes in non-small cell lung cancer patients associated with multi-antigenic RNActive® CV9201 immunotherapy

• Henoch Sangjoon Hong, Sven Dominik Koch, +9 authors James M. Billingsley
• Oncoimmunology
• 2016

We recently completed a phase I/IIa trial of RNActive® CV9201, a novel mRNA-based therapeutic vaccine targeting five tumor-associated antigens in non-small cell lung cancer (NSCLC) patients. The aim… (More)

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