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PURPOSE Tookad is a novel intravascular photosensitizer. When activated by 763 nm light, it destroys tumors by damaging their blood supply. It then clears rapidly from the circulatory system. To our knowledge we report the first application of Tookad vascular targeted photodynamic therapy in humans. We assessed the safety, pharmacokinetics and preliminary(More)
We demonstrate in the soft x-ray regime a novel technique for high-resolution lensless imaging based on differential holographic encoding. We have achieved superior resolution over x-ray Fourier transform holography while maintaining the signal-to-noise ratio and algorithmic simplicity. We obtain a resolution of 16 nm by synthesizing images in the Fourier(More)
We report on time-resolved coherent x-ray scattering experiments of laser induced magnetization dynamics in Co/Pd multilayers with a high repetition rate optical pump x-ray probe setup. Starting from a multi-domain ground state, the magnetization is uniformly reduced after excitation by an intense 50 fs laser pulse. Using the normalized time correlation, we(More)
X-ray magnetic circular dichroism measurements are reported at the beginning (W) and at the end (Ir, Pt) of the 5d series of the periodic table. Considerable induced magnetic moments of about 0.2 mu(B)/atom were probed for the nonmagnetic W and Ir and compared to previous data for the Pt induced moments in multilayers. W was found to couple(More)
PURPOSE To evaluate the 6-month effects of the recommended drug and light dosage in focal vascular-targeted photodynamic therapy (VTP) using TOOKAD(®) Soluble in patients with localized prostate cancer (LPCa). METHODS We performed a pooled analysis of 117 men with LPCa, PSA <10 ng/mL, and Gleason score ≤ 7 (3 + 4), from 3 studies who received a 10-min(More)
We introduce a noniterative image-reconstruction technique for coherent diffractive imaging. Through the application of differential and integral operators, an extended reference can be used to recover the complex-valued transmissivity of an object, in closed form, from a measurement of its far-field (Fraunhofer) diffraction intensity. We demonstrate the(More)
We show the ability to determine the relative phase between the object and a reference scatterer by tuning the overall intensity and phase of the reference wave. The proposed reference-guided phase retrieval algorithm uses the relative phase as a constraint to iteratively reconstruct the object and the reference simultaneously, and thus does not require(More)
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