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Inflammation contributes to brain damage caused by ischaemic stroke. Macrophages, as the prevailing inflammatory cell population in stroke lesions, can be visualized using ultrasmall superparamagnetic iron oxide (USPIO) as a cell-specific contrast agent for MRI. In this single-centre open-labelled clinical phase II study we tested the potential of(More)
In patients with primary aldosteronism, adrenal venous sampling is helpful to distinguish between unilateral and bilateral adrenal diseases. However, the procedure is technically challenging, and selective bilateral catheterization often fails. The aim of this analysis was to evaluate success rate in a retrospective analysis and compare data with procedures(More)
Brain inflammation contributes to the tissue injury caused by ischemic stroke. Macrophages as the most abundant inflammatory cell population in stroke lesions can be visualized using ultrasmall superparamagnetic iron oxide (USPIO) as a cell-specific contrast agent for magnetic resonance imaging (MRI). The aim of our present study was to delineate the(More)
BACKGROUND Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are complex tumors whose incidence is rising and whose treatment requires precise classification and risk stratification. METHOD Selective review of the relevant literature, including recently published guidelines. RESULTS GEP-NENs are initially classified by their degree of(More)
Pain is a complex experience with sensory, emotional and cognitive aspects. The cortical representation of pain - the pain matrix - consists of a network of regions including the primary (S1) and secondary (S2) sensory cortex, insula, and anterior cingulate cortex (ACC). These structures interact with brain regions such as the prefrontal cortex and the(More)
The visibility of a transjugular intrahepatic portosystemic stent-shunt (TIPS) puncture needle was assessed with use of real-time compound imaging and single-line ultrasonography (US). In vitro and in vivo, needle-tissue contrast was calculated. With an increasing angle of incidence, the decrease in needle visibility was more pronounced for single-line US(More)
BACKGROUND The anti-CD20 monoclonal antibody rituximab effectively depletes B lymphocytes and has been successfully used in the therapy of immune-mediated disorders of the peripheral nervous system. A limited effect of rituximab on B lymphocytes in the cerebrospinal fluid compartment of patients with primary progressive multiple sclerosis (MS) was recently(More)
BACKGROUND AND PURPOSE Inflammation contributes to brain damage caused by ischemic stroke. Ultrasmall superparamagnetic iron oxide (USPIO)-enhanced MRI allows noninvasive monitoring of macrophage recruitment into ischemic brain lesions. In this study, we determined the extent of USPIO enhancement during early stages of ischemic stroke. METHODS Twelve(More)
The purpose of this study was to assess the radiation exposure of patients in several standard protocols in multi-slice CT (MSCT). Scanning protocols for neck, chest, abdomen, and spine were examined on a Somatom Plus 4 Volume Zoom MSCT (Siemens, Erlangen, Germany) with changing slice collimation (4x1, 4x2.5, and 4x5 mm), and pitch factors (1, 1.5, and 2).(More)
Recently, macrophage infiltration in different central nervous system (CNS) pathologies has been visualized with ultrasmall particles of iron oxide (USPIO) as a new cell-specific contrast medium for MRI. However, validation of these findings at the histological level has been hampered by the fact that the in situ detection of iron uptake by conventional(More)