Andreas Plesch

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A new multicolor-banding technique has been developed which allows the differentiation of chromosome region specific areas at the band level. This technique is based on the use of differently labeled overlapping microdissection libraries. The changing fluorescence intensity ratios along the chromosomes are used to assign different pseudo-colors to specific(More)
Comparative genomic hybridization (CGH) has been used widely for the molecular cytogenetic analysis of tumors. Until now, the spatial resolution of this technique for diagnosing deletions of chromosomal sequences has not been assessed in detail. In the present study, we performed CGH analyses on five DNA samples derived from B-cell leukemias with 11q(More)
Field Trip A4: October 14th Lithofacies & Structure Of The Taconic Flysch, Melange, & Allochthon In The New York Capital District W.S.F. Kidd, A. Plesch, and F.W. Vollmer This trip will cover the full width of the deformed belt of Medial Ordovician flysch that outcrops adjacent to the Taconic Allochthon. It will include examination of the flatlying flysch(More)
Until now, few data on additional chromosomal aberrations in t(11;14)-positive mantle cell lymphomas (MCLs) have been published. We analyzed 39 t(11;14)-positive MCLs by either comparative genomic hybridization (CGH; n = 8), fluorescence in situ hybridization (FISH) with a set of DNA probes detecting the most frequent aberrations in B-cell neoplasms (n =(More)
Telomere length analysis has aroused considerable interest in biology and oncology. However, most published data are pan-genomic Southern-blot-based estimates. We developed T/C-FISH (telomere/centromere-FISH), allowing precise measurement of individual telomeres at every single chromosome arm. Metaphase preparations are co-hybridized with peptide nucleic(More)
We present a new three-dimensional model of the major fault systems in southern California. The model describes the San Andreas fault and associated strikeslip fault systems in the eastern California shear zone and Peninsular Ranges, as well as active blind-thrust and reverse faults in the Los Angeles basin and Transverse Ranges. The model consists of(More)
The quantification of DNA damage, both in vivo and in vitro, can be very time consuming, since large amounts of samples need to be scored. Additional uncertainties may arise due to the lack of documentation or by scoring biases. Image analysis automation is a possible strategy to cope with these difficulties and to generate a new quality of reproducibility.(More)
Michael Hausmann a,∗, Christoph Cremer b, Gustavo Linares-Cruz c, Thomas C. Nebe d, Katharina Peters e, Andreas Plesch f, Jochen Tham g, Michael Vetter h and Martin Werner a a Institute of Pathology, University Hospital Freiburg, Albertstr. 19, D-79104 Freiburg, Germany b Kirchhoff Institute of Physics, University of Heidelberg, Im Neuenheimer Feld 227,(More)
Imaging and documentation of the human retina for clinical diagnostics are conventionally achieved by classical optical methods. We designed a digital laser scanning fundus camera. The optoelectronical instrument is based on scanning laser illumination of the retina and a modified video imaging procedure. It is coupled to a digital image buffer and a(More)
OBJECTIVE A variety of methods have been used to select and identify fetal cells from maternal blood. In this study, a commonly used 3-step selection method is compared with selection directly from whole blood. Identification of fetal origin by XY FISH of male cells was also evaluated. METHODS Maternal blood was drawn either before invasive chorion villus(More)