Andreas M. Bartels

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Neuromodulation can change not only the mean firing rate of a neuron, but also its pattern of firing. Therefore, a reliable neu-ral coding scheme, whether a rate coding or a spike time based coding, must be robust in a dynamic neuromodulatory environment. The common observation that cholinergic modulation leads to a reduction in spike frequency adaptation(More)
Little is known about the constraints that neuromodulation places upon neural coding. We investigated the relationship between cholinergic modulation of spike timing and rate in a compartment model of a neocortical neuron. Our results suggest that cholinergic modulation of spike timing is directly related to the modulation of spike rate via the insertion of(More)
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