Learn More
The cancer cell secretome has emerged as an attractive subproteome for discovery of candidate blood-based biomarkers. To choose the best performing workflow, we assessed the performance of three first-dimension separation strategies prior to nanoLC-MS/MS analysis: (1) 1D gel electrophoresis (1DGE), (2) peptide SCX chromatography, and (3) tC2 protein(More)
In this paper we present a specific phonics based approach to supporting early literacy. The application system is cooperative and embedded in a "computer-integrated classroom". It provides an interactive writing environment using a visual palette of letters associated with icons and synthetic speech feedback for the writing results. Ongoing developments(More)
This paper describes a collaborative experiment with a special software application supporting the acquisition of initial reading and writing skills embedded in a computer-integrated environment for young children. The NIMIS project has set up three Computer-integrated Classrooms across Europe with appropriate " roomware " environments, i.e. furniture,(More)
The ability of Listeria monocytogenes to breach mucosal and endothelial barriers of the host during infection is a hallmark property mediated by the internalins (Inl) A and B. We examined the invasive property of several L. monocytogenes strains representing 13 serotypes. We found that invasiveness is a heterogeneous phenotype amongst L. monocytogenes(More)
This paper presents the concept of a collaborative computer integrated classroom (CiC) specially designed to achieve a unique combination of interactive and collaborative software with spatial arrangements, special furniture, and new peripherals including furniture (" roomware "). Although, technologically innovative, the CiC approach respects grown(More)
This paper describes a collaborative experiment in an early learners' classroom, equipped with special software and hardware to support the acquisition of initial reading and writing skills. This 'Computer-integrated Classroom' originated from the EU project NIMIS. Here, a new method to teach 'reading through writing' is supported by a specific software(More)
In this paper we present an approach of enriching grown structures of teaching in German schools with innovative technology and collaborative software tools. Two applications for collaborative modelling and mind mapping will be introduced. Together with a community of secondary school teachers we have elaborated classroom experiments which give an added(More)
Enriching existing classroom procedures and established pedagogic methods with computers is in no case a question of the number of computers available. In this paper, we present an approach of augmenting traditional structures of teaching at German schools by using innovative technology and collaborative software tools designed for the specific demands of(More)
" Collaborative mind tools " – a synthesis of two paradigms Over the last ten years, we have observed an increasing interest of the " computers in education " and other related research communities in supporting not only individual learners but also learning groups. The most prominent scenarios in this line of research and development have certainly been(More)