Andreas Kühn

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The quadrupole Orbitrap mass spectrometer (Q Exactive) made a powerful proteomics instrument available in a benchtop format. It significantly boosted the number of proteins analyzable per hour and has now evolved into a proteomics analysis workhorse for many laboratories. Here we describe the Q Exactive Plus and Q Exactive HF mass spectrometers, which(More)
In mass spectrometry-based proteomics, data-independent acquisition (DIA) strategies can acquire a single data set useful for both identification and quantification of detectable peptides in a complex mixture. However, DIA data are noisy owing to a typical five- to tenfold reduction in precursor selectivity compared to data obtained with data-dependent(More)
When a disaster occurs, the rapid gathering and sharing of crucial information among public safety agencies, emergency response units, and the public can save lives and reduce the scope of the problem; yet, this is seldom achieved. The lack of interoperability hinders effective collaboration across organizational and jurisdictional boundaries. In this(More)
The quantitative analysis of protein mixtures is pivotal for the understanding of variations in the proteome of living systems. Therefore, approaches have been recently devised that generally allow the relative quantitative analysis of peptides and proteins. Here we present proof of concept of the new metal-coded affinity tag (MeCAT) technique, which(More)
The focus of this paper is to establish a link of dynamic structures as found in software-based systems function descriptions to hardware implementations. Specific properties of object-oriented software methodologies and partially reconfigurable FPGAs are first analyzed. Then, both a reconfigurable processing unit and an approach how to map object classes(More)
— Garbage-Collection for reconfigurable hardware systems is another step to make dynamic reconfigurable hardware usable. By now, dynamic reconfiguration of FPGAs is still based on common hardware design concepts. This work describes a garbage-collector implementation for a reconfigurable hardware system, as part of a more dynamic hardware design concept. In(More)
Whereas languages with relatively fixed constituent order, such as English, mark association with focus primarily by means of accent placement, scrambling languages, such as German, obey linear order constraints for association with focus. We discuss how constituent order and intonation interact to license certain scopes for the semantic focus of focus(More)
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