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(2010) Long term dynamic modeling of global population and built-up area in a spatially explicit way, HYDE 3 .1, The Holocene 20(4), 565-573. Abstract This chapter describes a tool for long term global change studies; it is an update of the History Database of the Global Environment (HYDE) with estimates of some of the underlying demographic driving factors(More)
PURPOSE The Rs1h knockout mouse displays retinal features typical for X-linked juvenile retinoschisis (RS). Consequently, this mouse line represents an excellent model to study early molecular events in RS. METHODS Whole genome expression profiling using DNA-microarrays was performed on total RNA extracts from retinoschisin-deficient and wild-type murine(More)
Proof-of-concept for a successful adeno-associated virus serotype 5 (AAV5)-mediated gene therapy in X-linked juvenile retinoschisis (XLRS) has been demonstrated in an established mouse model for this condition. The initial studies concentrated on early time-points of treatment. In this study, we aimed to explore the consequences of single subretinal(More)
PURPOSE Tissue inhibitor of metalloprotease (TIMP)-3 is an inhibitor of matrix metalloprotease (MMP) and regulates angiogenesis. In the eye, TIMP3 is tightly associated with Bruch's membrane. In this study, the authors analyzed mice lacking TIMP3 for retinal abnormalities. METHODS Mice with targeted disruption of the Timp3 gene were generated (Timp3(-/-))(More)
(1) Preferences for three nesting materials and nest box positions were investigated simultaneously in two trials using a furnished cage: one with 18 individual laying hens and one with 18 groups of 5 hens. Following a habituation period in pre-test cages, every hen or group of hens was tested for 2 d: once without and once with plastic flaps at the(More)
The effect of static stretch and dynamic range of motion training on the flexibility of the hamstring muscles. Effects of two stretching methods on the range of motion, passive muscle tension and retention of flexibility. (2001a). Improvement of the range of motion and muscle passive tension during and after long-term stretching training. Gains in range of(More)
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