Learn More
Induced self expression of the NKp30 ligand B7-H6 facilitates NK cell-mediated elimination of stressed cells. A fusion protein consisting of the ectodomain of B7-H6 and the CD20 single-chain fragment variable 7D8 was generated to mimic an induced self phenotype required for NK cell-mediated target cell elimination. B7-H6:7D8 had bifunctional properties as(More)
The purpose of this prospective multi-center phase 2 trial was to investigate the long-term outcome of reduced-intensity conditioning allogeneic stem cell transplantation (alloSCT) in patients with poor-risk chronic lymphocytic leukemia. Conditioning was fludarabine/ cyclophosphamide-based. Longitudinal quantitative monitoring of minimal residual disease(More)
CD96, a cell surface antigen recently described to be preferentially expressed on acute myeloid leukemia (AML) leukemic stem cells (LSC) may represent an interesting target structure for the development of antibody-based therapeutic approaches. The v-regions from the CD96-specific hybridoma TH-111 were isolated and used to generate a CD96-specific single(More)
Acute myeloid leukemia (AML) is a clonal disorder preferentially affecting the blood and bone marrow and characterized by the accumulation of abnormally differentiated myeloid cells. Despite the existence of a variety of AML subgroups, AML seems to be organized hierarchically in at least three compartments: AML leukemic stem cells (LSCs), progenitor cells(More)
  • 1