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While todays orthography is very strict and seldom changes, this has not always been true. In historical texts spelling of words often not only varies from todays but in some periods even varies from use to use in a single text. Information retrieval on historical corpora can deal with these variations using fuzzy matching techniques based on(More)
Defects of the translation apparatus in human mitochondria are known to cause disease, yet details of how protein synthesis is regulated in this organelle remain to be unveiled. Ribosome production in all organisms studied thus far entails a complex, multistep pathway involving a number of auxiliary factors. This includes several RNA processing and(More)
With the new interest in historical documents insight grew that electronic access to these texts causes many specific problems. In the first part of the paper we survey the present role of digital historical documents. After collecting central facts and observations on historical language change we comment on the difficulties that result for retrieval and(More)
Collision times for the coinage metal atoms Cu, Ag and Au in He-droplets are derived from helium density functional theory and molecular dynamics simulations. The strength of the attractive interaction between the metal atoms turns out to be less important than the mass of the propagating metal atoms. Even for small droplets consisting of a few thousand(More)
He-droplet-induced changes of the hyperfine structure constants of alkali-metal atoms are investigated by a combination of relativistically corrected ab initio methods with a simulation of the helium density distribution based on He density functional theory. Starting from an accurate description of the variation of the hyperfine structure constant in the(More)
This article presents a case study of the user interface design of a grid (energy) management system. The theoretical backdrop of the case study is cognitive engineering, with its focus on supporting three levels of cognitive control, namely skill-, rules-, and knowledge-based control, respectively. In this design case study, the interface of the grid(More)
The ribosome is a highly dynamic machine responsible for protein synthesis within the cell. Cryo-electron microscopy (cryo-EM) and X-ray crystallography structures of ribosomal particles, alone and in complex with diverse ligands (protein factors, RNAs and small molecules), have revealed the dynamic nature of the ribosome and provided much needed insight(More)