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Sequence-based protein function and structure prediction depends crucially on sequence-search sensitivity and accuracy of the resulting sequence alignments. We present an open-source, general-purpose tool that represents both query and database sequences by profile hidden Markov models (HMMs): 'HMM-HMM-based lightning-fast iterative sequence search'(More)
With the new interest in historical documents insight grew that electronic access to these texts causes many specific problems. In the first part of the paper we survey the present role of digital historical documents. After collecting central facts and observations on historical language change we comment on the difficulties that result for retrieval and(More)
Due to the physico-chemical similarities of caesium (Cs(+)) to potassium (K(+)) on the one hand and strontium (Sr(2+)) to calcium (Ca(2+)) on the other hand, both elements can easily be taken up by plants and thus enter the food chain. This could be detrimental when radionuclides such as (137)Cs and (90)Sr are involved. In this study, both genetic and(More)
Defects of the translation apparatus in human mitochondria are known to cause disease, yet details of how protein synthesis is regulated in this organelle remain to be unveiled. Ribosome production in all organisms studied thus far entails a complex, multistep pathway involving a number of auxiliary factors. This includes several RNA processing and(More)
The ribosome is a highly dynamic machine responsible for protein synthesis within the cell. Cryo-electron microscopy (cryo-EM) and X-ray crystallography structures of ribosomal particles, alone and in complex with diverse ligands (protein factors, RNAs and small molecules), have revealed the dynamic nature of the ribosome and provided much needed insight(More)
In the covalently linked 2D coordination network {[Fe(bbtr)(3)](BF(4))(2)}(∞), bbtr = 1,4-di(1,2,3-triazol-1-yl)butane, the iron(II) centers stay in the high-spin (HS) state down to 10 K. They can, however, be quantitatively converted to the low-spin (LS) state by irradiating into the near-IR spin allowed (5)dd band and back again by irradiating into the(More)
This article presents a case study of the user interface design of a grid (energy) management system. The theoretical backdrop of the case study is cognitive engineering, with its focus on supporting three levels of cognitive control, namely skill-, rules-, and knowledge-based control, respectively. In this design case study, the interface of the grid(More)
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