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Sequence-based protein function and structure prediction depends crucially on sequence-search sensitivity and accuracy of the resulting sequence alignments. We present an open-source, general-purpose tool that represents both query and database sequences by profile hidden Markov models (HMMs): 'HMM-HMM-based lightning-fast iterative sequence search'(More)
Defects of the translation apparatus in human mitochondria are known to cause disease, yet details of how protein synthesis is regulated in this organelle remain to be unveiled. Ribosome production in all organisms studied thus far entails a complex, multistep pathway involving a number of auxiliary factors. This includes several RNA processing and(More)
With the new interest in historical documents insight grew that electronic access to these texts causes many specific problems. In the first part of the paper we survey the present role of digital historical documents. After collecting central facts and observations on historical language change we comment on the difficulties that result for retrieval and(More)
A summary of the technical advances that are incorporated in the fourth major release of the Q-CHEM quantum chemistry program is provided, covering approximately the last seven years. These include developments in density functional theory methods and algorithms, nuclear magnetic resonance (NMR) property evaluation, coupled cluster and perturbation(More)
This article presents a case study of the user interface design of a grid (energy) management system. The theoretical backdrop of the case study is cognitive engineering, with its focus on supporting three levels of cognitive control, namely skill-, rules-, and knowledge-based control, respectively. In this design case study, the interface of the grid(More)
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