Andreas Graf

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Having entered the mature human erythrocyte, the malaria parasite survives and propagates within a parasitophorous vacuole, a membrane-bound compartment separating the parasite from the host cell cytosol. The bounding membrane of this vacuole, referred to as the parasitophorous vacuolar membrane (PVM), contains parasite-encoded proteins, but how these(More)
Requirements engineering (RE) is a crucial aspect in systems development and is the area of ongoing research and process improvement. However, unlike in modelling, there has been no established standard that activities could converge on. In recent years, the emerging Requirements Interchange Format (RIF/ReqIF) gained more and more visibility in industry,(More)
Alteplase is standard therapy for patients with acute, massive pulmonary embolism. The novel plasminogen activator desmoteplase displays high fibrin specificity and selectivity for fibrinbound plasminogen. In a preclinical model desmoteplase was twice as potent with a shorter lysis time and lower reocclusion rate. We conducted a phase II study comparing(More)
Requirements Interchange Format (RIF/ReqIF) Submission for First Topcased Days Toulouse 2011 Andreas Graf, Michael Jastram 1 Overview One important step of the systems engineering process is requirements engineering. Parallel to the development of Topcased, which includes tooling for requirements engineering, a new standard for requirements exchange is(More)
This paper describes a programmable motion estimation processor applying a block matching technique on large search windows, Developed in the context of an MPEG-2 video encoder, its use can be extended to any application where fast motion estimation is required. Its high performance (17 Gops peak) and its ability to work in parallel make it ideal for real(More)
Large-scale land acquisitions are a reality in most regions worldwide. Vast areas of land are leased to foreign as well as national investors on a long term basis of 30-99 years. A growing number of reports, referring to this practice as ‘land grabbing’, show that these mostly very intransparent deals tend to go along with corruption, forced evictions and(More)