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BACKGROUND Treatment of long-standing complex regional pain syndrome (CRPS) is empirical and often of limited efficacy. Preliminary data suggest that the immune system is involved in sustaining this condition and that treatment with low-dose intravenous immunoglobulin (IVIG) may substantially reduce pain in some patients. OBJECTIVE To evaluate the(More)
Complex regional pain syndrome (CRPS) is a highly painful, limb-confined condition, which arises usually after trauma. It is associated with a particularly poor quality of life, and large health-care and societal costs. The causes of CRPS remain unknown. The condition's distinct combination of abnormalities includes limb-confined inflammation and tissue(More)
References 1. Koob MD, Moseley ML, Schut L], et al. An untranslated CTG expansion causes a novel form of spinocerebellar ataxia (SCA8). 1 Immune factors have been implicated in chronic pain, 1 and patients with complex regional pain syndrome (CRPS) ap­ pear to respond to intravenolls immunoglobulins (IVIGS).2 A woman with CRPSI recorded more than 50% pain(More)
Complex regional pain syndrome (CRPS) is a disabling pain condition with sensory, motor and autonomic manifestations. Uncertainty remains about how CRPS can be effectively managed. We conducted a systematic review of randomized controlled trials (RCTs) for treatment and prophylactic interventions for CRPS published during the period 2000-2012, building on(More)
Complex regional pain syndrome (CRPS) is a painful condition affecting one or more extremities of the body, marked by a wide variety of symptoms and signs that are often difficult to manage because the pathophysiology is incompletely understood. Thus, diverse treatments might be ineffective. A recent report revealed the presence of autoantibodies against(More)
A homomorphism from a graph <i>G</i> to a graph <i>H</i> is a function from <i>V</i>(<i>G</i>) to <i>V</i>(<i>H</i>) that preserves edges. Many combinatorial structures that arise in mathematics and in computer science can be represented naturally as graph homomorphisms and as weighted sums of graph homomorphisms. In this article, we study the complexity of(More)
BACKGROUND Both increased mast cells numbers and raised immune mediator concentrations indicate immune activation in the affected skin of patients with early complex regional pain syndrome (CRPS), but little is known about regional immune cell involvement in late-stage CRPS. The aim of the current study was to determine skin immune cell populations in(More)
OBJECTIVE To examine the use of intravenous immunoglobulin (i.v.i.g.) in chronic pain. DESIGN A prospective multiple-dose, open-label cohort study in 130 consecutive patients who suffered from 12 chronic pain syndromes. The largest symptom groups were (number of patients): Fibromyalgia (48); Spinal pain (20); Complex regional pain syndrome (CRPS, 11);(More)
We hypothesised that some complex regional pain syndromes (CRPS) may have a postinfectious and/or autoimmune basis. Sera from 92 patients with CRPS and 92 controls were investigated for immunoreactivity to Campylobacter strains and to rodent tissues. Both IgA-antibodies to Campylobacter and tissue-specific reactivity were often present in patients with(More)