Andreas Fischer

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The discovery and optimization of a novel triorganotin(IV) complexes with anti-HCV properties are presented. Organotin(IV) moiety has the ability to bind phosphate group of RNA backbone. The organotin(IV) moiety is bonded with ligands and groups, which are known for inhibiting HCV enzymes. Triorganotin(IV) complexes were synthesized and evaluated for their(More)
—In order to improve the safety, lifetime, and energy efficiency of turbomachines, the dynamic behavior of the rotor has to be analyzed. Blade vibrations have to be monitored during operation to optimize the rotor design and to validate numerical models. However, measuring the vibration amplitude and frequency of the blades is a challenging task for(More)
CRYSTALS OF THE HYDROGEN SULFATE SALT OF CHLORDIAZEPOXIDE (SYSTEMATIC NAME: 7-chloro-N-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-iminium 4-oxide hydrogen sulfate), C(16)H(15)ClN(3)O(+)·HSO(4) (-), were obtained from a solution of chlordiazepoxide and sulfuric acid in methanol. The structure features chlordiazepoxide mol-ecules that are protonated(More)
IN THE TITLE COMPOUND (SYSTEMATIC NAME 7-chloro-2-methyl-amino-5-phenyl-3H-1,4-benzodiazepine 4-oxide dichloro-meth-ane monosolvate), C(16)H(14)ClN(3)O·CH(2)Cl(2), the seven-membered ring adopts a boat conformation with the CH(2) group as the prow and the two aromatic C atoms as the stern. The dihedral angle between the benzene rings is 75.25 (6)°. The(More)
In the title mol-ecule, C(10)H(8)FNO(3), the dihedral angle between the fluoro-phenyl group and the essentially planar [within 0.064 (3) Å] COC=CCOOH unit, which has a Z configuration, is 19.99 (14)°. There is an intra-molecular O-H⋯O bond in the mol-ecule involving the acid -OH group and the adjacent carbonyl O atom. In the crystal, inter-molecular N-H⋯O(More)
A monoclinic polymorph of theophylline, C(7)H(8)N(4)O(2), has been obtained from a chloro-form/methanol mixture by evaporation under ambient conditions. The new polymorph crystallizes with two mol-ecules in the asymmetric unit. The structure features inter-molecular N-H⋯O hydrogen bonds, resulting in the formation of dimers between two crystallographically(More)