Learn More
We consider nonlinear programs with inequality constraints, and we focus on the problem of identifying those constraints which will be active at an isolated local solution. The correct identification of active constraints is important from both a theoretical and a practical point of view. Such an identification removes the combinatorial aspect of the(More)
To identify genes involved in the regulation and execution of leaf senescence and whole-plant nitrogen reallocation, near-isogenic barley germplasm divergent in senescence timing and protein concentration of mature grains was contrasted. Barley lines differing in allelic state at a major locus on chromosome six, controlling grain protein concentration, were(More)
We define a new Newton-type method for the solution of constrained systems of equations and analyze in detail its properties. Under suitable conditions, that do not include differentiability or local uniqueness of solutions, the method converges locally quadratically to a solution of the system of equations, thus filling an important gap in the existing(More)
The Delta-Notch signaling pathway plays a central role in the development of most vertebrate organs. The Hey family of bHLH transcription factors are direct targets of Notch signaling. Loss of Hey2 in the mouse leads to cardiac defects with high postnatal lethality. We have now generated a mouse Hey1 knockout that has no apparent phenotypic defect. The(More)
The generalized Nash equilibrium problem, where the feasible sets of the players may depend on the other players' strategies, is emerging as an important modeling tool. However, its use is limited by its great analytical complexity. We consider several Newton methods, analyze their features and compare their range of applicability. We illustrate in detail(More)
We consider a class of Newton-type methods for constrained systems of equations that involve complementarity conditions. In particular, at issue are the constrained Levenberg–Marquardt method and the recently introduced Linear-Programming-Newton method, designed for the difficult case when solutions need not be isolated, and the equation mapping need not be(More)
Cerebral cavernous malformations (CCM) are frequent vascular abnormalities caused by mutations in one of the CCM genes. CCM1 (also known as KRIT1) stabilizes endothelial junctions and is essential for vascular morphogenesis in mouse embryos. However, cellular functions of CCM1 during the early steps of the CCM pathogenesis remain unknown. We show here that(More)
Leaf senescence can be described as the dismantling of cellular components during a specific time interval before cell death. This has the effect of remobilizing N in the form of amino acids that can be relocalized to developing seeds. High levels of carbohydrates have previously been shown to promote the onset of the senescence process. Carbohydrate(More)