Andreas Ecke

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Antagonists of the mineralocorticoid receptor improve morbidity and mortality in patients with severe heart failure. However, the cell types involved in these beneficial effects are only partially known. The aim of this work was to evaluate whether genetic deletion of mineralocorticoid receptors in mouse cardiomyocytes or fibroblasts in vivo is(More)
In Description Logics (DL) knowledge bases (KBs), information is typically captured by clear-cut concepts. For many practical applications querying the KB by crisp concepts is too restrictive; a user might be willing to lose some precision in the query, in exchange of a larger selection of answers. Similarity measures can offer a controlled way of gradually(More)
Completion algorithms for subsumption are investigated for many extensions of the description logic EL. While for several of them subsumption is tractable, this is no longer the case, if inverse roles are admitted. In this paper we present an optimized version of the completion algorithm for ELHIfR+ [11], which is implemented in jCel. The completion sets(More)
Ontologies are used to represent and share knowledge. Numerous ontologies have been developed so far, especially in knowledge intensive areas such as the biomedical domain. As the size of ontologies increases, their continued development and maintenance is becoming more challenging as well. Detecting and representing semantic differences between versions of(More)
For EL the least common subsumer (lcs) need not exist, if computed w.r.t. general TBoxes. In case the role-depth of the lcs concept description is bounded, an approximate solution can be obtained. In this paper we extend the completion-based method for computing such approximate solutions to ELI and EL+. For ELI the extension needs to be able to treat(More)
In Description Logic (DL) knowledge bases (KBs) information is typically captured by crisp concepts. For many applications, querying the KB by crisp query concepts is too restrictive. A controlled way of gradually relaxing a query concept can be achieved by the use of concept similarity measures. In this paper we formalize the task of instance query(More)
In Description Logics (DL) knowledge bases (KBs) information is typically captured by crisp concept descriptions. However, for many practical applications querying the KB by crisp concepts is too restrictive. A controlled way of gradually relaxing a query concept can be achieved by the use of similarity measures. To this end we formalize the task of(More)
Description Logics (DLs) are a family of knowledge representation formalisms, that provides the theoretical basis for the standard web ontology language OWL. Generalization services like the least common subsumer (lcs) and the most specific concept (msc) are the basis of several ontology design methods, and form the core of similarity measures. For the DL(More)
Completion-based algorithms can be employed for computing the least common subsumer of two concepts up to a given role-depth, in extensions of the lightweight DL EL. This approach has been applied also to the probabilistic DL Prob-EL, which is variant of EL with subjective probabilities. In this paper we extend the completion-based lcscomputation algorithm(More)
a r t i c l e i n f o a b s t r a c t Article history: Available online xxxx Description Logics (DLs) are a well-established family of knowledge representation formalisms. One of its members, the DL ELOR has been successfully used for representing knowledge from the bio-medical sciences, and is the basis for the OWL 2 EL profile of the standard ontology(More)