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Improved diagnosis and treatment of traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) are needed for our military and veterans, their families, and society at large. Advances in brain imaging offer important biomarkers of structural, functional, and metabolic information concerning the brain. This article reviews the application of(More)
BACKGROUND AND PURPOSE Poor clinical outcomes without notable neuroimaging findings after mild traumatic brain injury (MTBI) suggest diffuse tissue damage and altered metabolism not observable with conventional MR imaging and CT. In this study, MTBI-associated metabolic changes were assessed over the entire brain by using volumetric proton MR spectroscopic(More)
Image reconstruction for magnetic resonance spectroscopic imaging (MRSI) requires specialized spatial and spectral data processing methods and benefits from the use of several sources of prior information that are not commonly available, including MRI-derived tissue segmentation, morphological analysis and spectral characteristics of the observed(More)
For many clinical applications of proton MR spectroscopic imaging (MRSI) of the brain, diagnostic assessment is limited by insufficient coverage provided by single- or multislice acquisition methods as well as by the use of volume preselection methods. Additionally, traditional spectral analysis methods may limit the operator to detailed analysis of only a(More)
Spectral quality in 1H magnetic resonance spectroscopic imaging (MRSI) critically depends on the stability of the main magnetic field. For echo-planar MRSI implemented at 3 T, temperature variation in the passive steel shims of the magnet system can lead to a significant drift in the resonance frequency. A method is presented that incorporates interleaved(More)
Spectral quality in (1)H MR spectroscopic imaging (MRSI) of the brain is often significantly degraded in regions subject to local magnetic susceptibility variations, which results in broadened and distorted spectral lineshapes. In this report, a modified acquisition strategy for volumetric echo-planar spectroscopic imaging (3D EPSI) is presented that(More)
High-spatial-resolution acquisition (HR) was previously proposed for 3D echo-planar spectroscopic imaging (EPSI) in combination with a high-spatial-resolution water reference EPSI data set to minimize inhomogeneous spectral line broadening, allowing for local frequency shift (B(0) shift) correction in human brain metabolite maps at 1.5 T (Ebel A et al.,(More)
To reduce contamination from subcutaneous lipid regions in MR spectroscopic imaging (MRSI) of whole brain, lipid signals are often suppressed using T(1) nulling methods. If a range of lipid T(1) values is present, the suppression efficiency will be improved using multiple inversion recovery (MIR) preparation. This study compared single IR (SIR) and double(More)
The influence of noise on the standard deviation of spectral integrals is examined. Calculations assuming discrete Fourier-transform data are compared with Monte-Carlo simulations. The effects of zero-filling and apodization are examined for free-induction-decay (FID) signals and for symmetric spin-echo signals in one and two dimensions, with particular(More)
Model-based techniques have the potential to reduce the artifacts and improve resolution in magnetic resonance spectroscopic imaging, without sacrificing the signal-to-noise ratio. However, the current approaches have a few drawbacks that limit their performance in practical applications. Specifically, the classical schemes use less flexible image models(More)