Andreas Brueckmann

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BACKGROUND A high complication rate of Q fever in pregnancy is described on the basis of a limited number of cases. All pregnant women with proven Q fever regardless of clinical symptoms should therefore receive long-term cotrimoxazole therapy. But cotrimoxazole as a folic acid antagonist may cause harm to the fetus. We therefore investigated the Q fever(More)
PURPOSE To measure static and dynamic changes of retinal vessels in response to normobaric hypoxia (NH, study A) and hypobaric hypoxia (HH, study B). METHODS Study A included 10 healthy individuals exposed to a simulated altitude of 5500 meters in a NH chamber; study B included 17 individuals studied after ascent to 3000-meter altitude. Retinal vessel(More)
PURPOSE NO-triggered vasodilatation decreases peripheral vascular resistance in pregnancy. Using a noninvasive ultrasound technique, flow-mediated vasodilatation can be quantified. We used this technique to detect changes in endothelial function during pregnancy and postpartum. MATERIALS AND METHODS In a prospective longitudinal study 16 healthy pregnant(More)
Flicker-induced dilatation is reduced in patients with cardiovascular risk, and the following arteriolar constriction is reduced with aging, leading to a reduced arteriolar amplitude and, thereby, indicating microvascular endothelial dysfunction. As endothelial dysfunction is associated with preeclampsia, we assessed retinal flicker response during(More)
INTRODUCTION Retinal changes are known in severe preeclampsia (PE). This is the first study evaluating static retinal vessel analysis in pregnancy to measure retinal vessel diameter and in women destined to develop preeclampsia. METHODS 51 non-pregnant controls (29±4 years) and 601 pregnant women (30±6 years) arterio-venous ratio (AVR) of retinal(More)
OBJECTIVE To assess critical flicker frequency (CFF) in normal uneventful pregnancy and preeclampsia. STUDY-DESIGN Case-control observational study at the University Hospital Jena and Outpatient Institute for Prenatal Diagnosis and Preventive Medicine. 25 non-pregnant women, 75 uncomplicated pregnant women in first, second and third trimester, and 15(More)
INTRODUCTION Gestational diabetes (GMD) is gaining in importance in prenatal care due to it's increasing prevalence. These women do have a higher risk for disrupted elasticity and stiffening of the carotid artery. Aim of this study was to assess carotid intima media thickness (IMT) and vessel wall changes during pregnancy and postpartum. METHODS IMT and(More)
INTRODUCTION Carotid intima media thickness (IMT) is an established marker for endothelial dysfunction and cardiovascular risk. The aim of this study was to assess IMT in the first trimester and it's predictive value for preeclampsia. METHOD We measured IMT on 51 non-pregnant controls (29±4 years) and 601 pregnant women (30±6 years) in the 1. (12.1±2.5(More)
Background Chronic heart failure (CHF) is the leading cause of hospitalization and death in industrialized countries. CHF is frequently associated with humoral and metabolic disturbances, including reduced bioavailability of the important signalling molecule nitric oxide (NO), which has vasodilating properties. Several studies reported high plasma levels of(More)
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