Andreas Brauers

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cDNA clones of two novel Ras-related GTP-binding proteins (RagA and RagB) were isolated from rat and human cDNA libraries. Their deduced amino acid sequences comprise four of the six known conserved GTP-binding motifs (PM1, -2, -3, G1), the remaining two (G2, G3) being strikingly different from those of the Ras family, and an unusually large C-terminal(More)
GLUT8 is a novel glucose transporter-like protein that exhibits significant sequence similarity with the members of the sugar transport facilitator family (29.4% of amino acids identical with GLUT1). Human and mouse sequence (86.2% identical amino acids) comprise 12 putative membrane-spanning helices and several conserved motifs (sugar transporter(More)
A single contact-less mechanical sensor is exploited for estimating three vital signs during sleep, namely, the heart rate, the breathing rate and an activity index related to the body movements. Robust estimations are achieved over epochs of 30 seconds. The data processing is performed with standard DSP techniques leading to an integrated solution for(More)
PURPOSE We evaluated the prognostic significance of a second transurethral resection in patients with moderately and poorly differentiated T1 bladder cancer. MATERIALS AND METHODS A total of 47 patients with primary T1 bladder cancer were evaluated. A second transurethral resection was performed in 42 patients in case of moderately or poorly(More)
We present an algorithm for obtaining the heart rate from the signal of a single, contact-less sensor recording the mechanical activity of the heart. This vital parameter is required on a beat-to-beat basis for applications in sleep analysis and heart failure disease management. Our approach bundles information from various sources for first robust(More)
This study was designed to analyze the cytochrome P450 isoenzyme mRNA expression pattern of transitional cell carcinomas of the bladder (N = 19) and normal urothelium (N = 10). In addition, biopsies from normal urothelium (N = 32) taken at the time of transurethral resection of bladder cancer in eight patients from surrounding histologically normal(More)
OBJECTIVE To compare the ability of magnetic resonance urography (MRU), enhanced using gadolinium and frusemide diuresis, and conventional intravenous urography (IVU) to diagnose the cause of ureteric obstruction. PATIENTS AND METHODS The study included 82 patients in whom IVU showed or suggested obstruction and who also underwent MRU. The images from(More)
RATIONALE AND OBJECTIVES The authors distinguish the histomorphologic subtypes of renal cell tumors (RCTs) by computed tomography (CT). METHODS In a consensus conference between radiologists, pathologists, and urologists, the CT criteria of the various subtypes of RCTs (clear cell, chromophilic cell, chromophobic cell renal carcinoma and oncocytoma) were(More)
Prostate stem cell antigen (PSCA) is a member of the LY-6 family of surface proteins that is overexpressed in prostate cancer. Using serial analysis of gene expression (SAGE), we identified PSCA as one of the most abundant transcripts in a differentiated urothelial tumor. As assessed by Northern blotting, PSCA is highly expressed in normal urothelium and(More)
Increased levels of mRNA transcribed from the ob gene in adipose tissue of obese/hyperin-sulinaemic Zucker (fa/fa) rats were detectable as early as 3 weeks after birth and continued to rise there after in parallel with body weight and serum insulin. mRNA levels of two other fat-specific genes (ARL4, FST44) were unaltered. In C57BL/KsJ db/db mice, ob mRNA(More)