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Synthesis and biological evaluation of thioadatanserin and its dialkylated products as partial 5-HTR1A agonists and 5-HTR2A antagonists for potential use in depression and anxiety disorders.
- C. Evans, Andrea Zuluaga, Diego Vasquez Matute, Sarah Baradaran-Noviri, Natalia Perez-Cervantes, M. Siegler
- Medicine, Chemistry
- Bioorganic & medicinal chemistry letters
- 15 August 2020
Thionation of adatanserin hydrochloride (2) with Lawesson's reagent in toluene/triethylamine afforded novel compound,… Expand